Influence of a 100-km ultra-marathon on hepatitis B carrier runners
Deutscher übersetzter Titel: | Einfluss eines 100-km-Ultramarathons auf Läufer mit Hepatitis B |
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Autor: | Chiu, Y.-H.; Hou, S.-K.; How, C.-K.; Li, L.-H.; Kao, Wei-Fong; Yang, C.-C.; Chou, S.-L.; Shiau, Y.-T.S.; Lam, C.; Chen, R.-J. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 34 (2013), 9, S. 841-845, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-0032-1331769 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201311007495 |
Quelle: | BISp |
Abstract
This study compares the serological markers between runners who are hepatitis B virus carries (HBVc) and runners who are non-HBVc in a 100-km ultra-marathon race. Blood samples of 8 HBVc and 18 non-HBVc runners were drawn 1 week before, immediately following, and 24 h after the race. Samples were analyzed and compared between the 2 groups for liver function tests, muscle damage markers and oxidative stress cytokines. For HBVc runners, HBV-DNA (hepatitis B virus-deoxyribonucleic acid) levels were also evaluated for virus reactivation. The results demonstrate a statistically significant increase in both immediate and 24-h post-race values for alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), compared with pre-race values. No statistically significant difference was observed between the 2 groups for the values of AST, LDH, CK, hs-CRP, IL-6 and TNF-α either before or after the race. There was also no statistically significant change in the levels of HBV-DNA in HBVc runners. These findings suggest that HBVc runners do not have higher risks of liver function impairment, muscle breakdown and inflammatory response compared to non-HBVc runners in such endurance races. Verf.-Referat