TY  - JOUR
AU  - Schoenfeld, Brad Jon
A2  - Schoenfeld, Brad Jon
DB  - BISp
DP  - BISp
KW  - Antiphlogistikum
KW  - Forschung, empirische
KW  - Forschungsstand
KW  - Literaturübersicht
KW  - Muskelhypertrophie
KW  - Muskelphysiologie
KW  - Pharmakologie
KW  - Pharmakon
KW  - Protein
KW  - Satellitenzellen
KW  - Skelettmuskulatur
KW  - Sportmedizin
KW  - Therapie, medikamentöse
LA  - eng
TI  - The use of nonsteroidal anti-inflammatory drugs for exercise-induced muscle damage : implications for skeletal muscle development
TT  - Die Anwendung nicht-steroidaler anti-inflammatorischer Medikamente bei belastungsinduzierter Muskelschädigung : Implikationen für den Muskelaufbau
PY  - 2012
N2  - Exercise-induced muscle damage (EIMD) is a common condition resulting from a bout of vigorous exercise, particularly if the individual is unaccustomed to performance of the given movement. Symptoms of EIMD include delayed-onset muscle soreness (DOMS) and a loss of physical function. Nonsteroidal anti-inflammatory drugs (NSAIDs) are routinely prescribed post-exercise to alleviate these symptoms and restore normal physical function. Of potential concern for those who use NSAIDs to treat EIMD is the possibility that they may impair the adaptive response to exercise. Specifically, there is emerging evidence that the action of cyclo-oxygenase (COX) enzymes, and COX-2 in particular, are important and even necessary to achieve maximal skeletal muscle hypertrophy in response to functional overload. Given that NSAIDs exert their actions by blocking COX and thus suppressing prostaglandin production, a theoretical rationale exists whereby these drugs may have detrimental effects on muscle regeneration and supercompensation. Therefore, the purpose of this article is to extensively review the literature and evaluate the effects of NSAIDs on muscle growth and development. Based on current evidence, there is little reason to believe that the occasional use of NSAIDs will negatively affect muscle growth, although the efficacy for their use in alleviating inflammatory symptoms remains questionable. Evidence on the hypertrophic effects of the chronic use of NSAIDs is less clear. In those who are untrained, it does not appear that regular NSAID use will impede growth in the short term, and at least one study indicates that it may in fact have a positive impact. Given their reported impairment of satellite cell activity, however, longer-term NSAID use may well be detrimental, particularly in those who possess greater growth potential. Verf.-Referat
L2  - https://dx.doi.org/10.2165/11635190-000000000-00000
DO  - 10.2165/11635190-000000000-00000
SP  - S. 1017-1028
SN  - 0112-1642
JO  - Sports medicine
IS  - 12
VL  - 42
M3  - Gedruckte Ressource
M3  - Elektronische Ressource (online)
ID  - PU201301000345
ER  -