Excretion study of budesonide metabolites after inhalation and oral administration using LC-ESI-MS/MS
| Deutscher übersetzter Titel: | Die Exkretionsstudie von Budesonid-Metaboliten nach Inhalation und oraler Verabreichung mittels LC-ESI-MS/MS |
|---|---|
| Autor: | Oueslati, F.; Siaї, A.; Hentati, E.; Ben Amor, S.; Fenina, N.; Loueslati, M.H. |
| Erschienen in: | Recent advances in doping analysis (19) : Proceedings of the Manfred-Donike-Workshop ; 29th Cologne Workshop on Dope Analysis ; 13th to 18th February 2011 |
| Veröffentlicht: | Köln: Sportverl. Strauß (Verlag), 2011, S. 166-169, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Elektronische Ressource (Datenträger) |
| Sprache: | Englisch |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201211007381 |
| Quelle: | BISp |
Abstract
Budesonide (BUD) is a corticosteroid, clinically used in the treatment of respiratory diseases, such as asthma and rhinitis. Several studies have been reported for the determination of BUD and its metabolites in biological samples. Despite this, there are a few data on the detection of BUD and its metabolites associated to doping analysis. In addition, no reports on the urinary excretion profiles of this corticosteroid and its metabolites have been so far described. The present work describes a sensitive and specific LC-ESI-MS/MS method for the identification of BUD metabolites in urine after inhalation and oral administration. Five BUD metabolites were therefore separated and identified. Analysis of urine samples taken after inhalation of Budiar® (5x400 µg) and ingestion of three capsules of Entocort® (3x3 mg) revealed that the five metabolites could be detected up to 50 hours after administration. Einleitung