Zeranol - doping offence or mycotoxin? : a case-related study
Gespeichert in:
| Deutscher übersetzter Titel: | Zeranol - Dopingvergehen oder Mycotoxin? : eine fallbasierte Untersuchung |
|---|---|
| Autor: | Thevis, Mario; Fußhöller, Gregor; Schänzer, Wilhelm |
| Erschienen in: | Drug testing and analysis |
| Veröffentlicht: | 3 (2011), 11/12 (29th Cologne Workshop: Advances in Sports Drug Testing), S. 777-783, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
| Sprache: | Englisch |
| ISSN: | 1942-7603, 1942-7611 |
| DOI: | 10.1002/dta.352 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201203001728 |
| Quelle: | BISp |
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PU201203001728 |
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db |
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Literatur |
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2022-08-18T10:17:00Z |
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2012-03-20T11:12:21Z |
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BISp |
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Zeitschriftenartikel |
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JO00000100376 |
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JOI201112910100376 |
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Drug testing and analysis |
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Drug testing and analysis, 2011, 11/12 |
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PU201203001728 |
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Zeranol - doping offence or mycotoxin? : a case-related study |
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0777 |
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bisparticle |
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2011 |
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2011 |
| language |
eng |
| title |
Zeranol - doping offence or mycotoxin? : a case-related study |
| spellingShingle |
Zeranol - doping offence or mycotoxin? : a case-related study Biochemie Doping Dopingbekämpfung Dopingkontrolle Dopingnachweis Fallstudie Gaschromatographie Massenspektrometrie Metabolit Steroid, anaboles Urinuntersuchung |
| title_sort |
zeranol doping offence or mycotoxin a caserelated study |
| title_short |
Zeranol - doping offence or mycotoxin? : a case-related study |
| title_alt |
Zeranol - Dopingvergehen oder Mycotoxin? : eine fallbasierte Untersuchung |
| title_alt_lang |
deu |
| media_type |
Gedruckte Ressource Elektronische Ressource (online) |
| city |
Chichester |
| abstract |
Zeranol ((7R,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-13-one, also referred to as 7α-zearalanol, Ralone®, Frideron®, Ralgro®, etc.) is a semi-synthetic estrogenic veterinary drug with growth-promoting properties. Its use regarding animal husbandry has been prohibited in the European Union since 1981 and, due to its anabolic effects, it is further recognized as a banned substance in sport. Numerous studies were conducted concerning the identification of the illicit application of zeranol to domestic livestock. These studies also considered the natural occurrence of zeranol as a metabolite of the mycotoxin zearalenone and the issue of differentiating both scenarios, i.e. illegal use or unintended contamination. Human sports drug testing authorities are facing comparable challenges since the deliberate misuse of the (for human application non-approved) drug should be discriminated from adverse analytical findings resulting from the biotransformation of the mycotoxin zearalenone possibly ingested with contaminated food. The active drug (zeranol), its major human metabolites (zearalanone, 7β-zearalanol) and the mycotoxin (zearalenone) plus its major and unique metabolic products (α-zearalenol, β-zearalenol) have been monitored in routine doping controls by means of validated gas chromatography-(tandem) mass spectrometry (GC-(MS/)MS) methods since 1996, and between 2005 and 2010 four samples providing suspicious signals were detected. In agreement with literature data, in vitro metabolism studies demonstrated the metabolic pathway from zearalenone towards zeranol (and common metabolites). In contrast, an administration study urine sample (collected after oral application of 20 mg of zeranol) yielded only ultra-trace amounts of zearalenone and its characteristic metabolites, which supported the assumption that a mycotoxin contamination caused the finding of zeranol in the doping control specimens rather than a misuse of the anabolic agent. Verf.-Referat |
| abstract_lang |
eng |
| abstract_type |
abstract |
| author2 |
Thevis, Mario Fußhöller, Gregor Schänzer, Wilhelm |
| author_facet |
Thevis, Mario Fußhöller, Gregor Schänzer, Wilhelm |
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Autor Autor Autor |
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P122169 P153209 P72 |
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Thevis, Mario Fußhöller, Gregor Schänzer, Wilhelm |
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Fusshöller, Gregor Schaenzer, Wilhelm |
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0/Autor/ 1/Autor/Thevis, Mario/ 0/Autor/ 1/Autor/Fußhöller, Gregor/ 0/Autor/ 1/Autor/Schänzer, Wilhelm/ |
| doi |
10.1002/dta.352 |
| spelling |
10.1002/dta.352 1942-7603 1942-7611 2462336-2 Biochemie Doping Dopingbekämpfung Dopingkontrolle Dopingnachweis Fallstudie Gaschromatographie Massenspektrometrie Metabolit Steroid, anaboles Urinuntersuchung anabolic steroid biochemistry case study doping doping control doping detection fight against doping gas chromatography mass spectrometry metabolite urine examination Dopingmittel Dopinganalyse Stoffwechselprodukt Anabolikum Dianabol Retabolil Zeranol - doping offence or mycotoxin? : a case-related study PU201203001728 201203001728 |
| url |
https://dx.doi.org/10.1002/dta.352 |
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fulltext |
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1 |
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1 |
| issn |
1942-7603 1942-7611 |
| zdb |
2462336-2 |
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0/Großbritannien/ 1/Großbritannien/England/ |
| topic |
Biochemie Doping Dopingbekämpfung Dopingkontrolle Dopingnachweis Fallstudie Gaschromatographie Massenspektrometrie Metabolit Steroid, anaboles Urinuntersuchung |
| topic_facet |
Biochemie Doping Dopingbekämpfung Dopingkontrolle Dopingnachweis Fallstudie Gaschromatographie Massenspektrometrie Metabolit Steroid, anaboles Urinuntersuchung |
| topic_en |
anabolic steroid biochemistry case study doping doping control doping detection fight against doping gas chromatography mass spectrometry metabolite urine examination |
| topic_en_facet |
anabolic steroid biochemistry case study doping doping control doping detection fight against doping gas chromatography mass spectrometry metabolite urine examination |
| synonym |
Dopingmittel Dopinganalyse Stoffwechselprodukt Anabolikum Dianabol Retabolil |
| journal_facet |
Drug testing and analysis |
| container_title |
Drug testing and analysis |
| container_volume |
3 |
| container_issue |
11/12 |
| container_start_page |
S. 777-783 |
| container_special_issue |
29th Cologne Workshop: Advances in Sports Drug Testing |
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1 |
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BISp |
| journal_fac |
JO00000100376 |
| journal_year |
2011 |
| journal_issue |
11/12 |
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1797309818177847296 |
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13,05066 |