A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners

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Deutscher übersetzter Titel:Ein Halbmarathon- und ein Marathonlauf verursacht oxidative DNS-Schädigung, reduziert die antioxidative Kapazität, die gegen DNS-Schädigungen schützt und verändert die Immunfunktion bei Hobbyläufern
Autor:Briviba, Karlis; Watzl, Bernhard; Nickel, Kerstin; Kulling, Sabine; Bös, Klaus; Härtel, Sascha; Rechkemmer, Gerhard; Bub, Achim
Erschienen in:Redox report
Veröffentlicht:10 (2005), 6, S. 325-331, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Gedruckte Ressource
Sprache:Englisch
ISSN:1351-0002, 1743-2928
Schlagworte:
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Erfassungsnummer:PU201108007425
Quelle:BISp
id PU201108007425
bisp-collection db
format Literatur
last_indexed 2011-08-31T11:39:18Z
first_indexed 2011-08-31T11:27:51Z
publication_source BISp
subformat Zeitschriftenartikel
hierarchy_top_id JO00000101028
hierarchy_parent_id JOI200500060101028
hierarchy_top_title Redox report
hierarchy_parent_title Redox report, 2005, 6
is_hierarchy_id PU201108007425
is_hierarchy_title A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners
hierarchy_sequence 0325
recordtype bisparticle
publishDate 2005
publishDate_facet 2005
language eng
title A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners
spellingShingle A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners
Desoxyribonukleinsäure
Fallstudie
Freizeitsport
Halbmarathon
Immunsystem
Kapazität, antioxidative
Lymphozyt
Marathonlauf
Sportmedizin
Sportwissenschaft
title_sort a halfmarathon and a marathon run induce oxidative dna damage reduce antioxidant capacity to protect dna against damage and modify immune function in hobby runners
title_short A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners
title_alt Ein Halbmarathon- und ein Marathonlauf verursacht oxidative DNS-Schädigung, reduziert die antioxidative Kapazität, die gegen DNS-Schädigungen schützt und verändert die Immunfunktion bei Hobbyläufern
title_alt_lang deu
media_type Gedruckte Ressource
city Leeds
abstract This study investigated whether a 21.1 km (half-marathon) or a 42.195 km (marathon) run modulates DNA damage, antioxidant capacity in lymphocytes and plasma, and the immune system in healthy hobby runners. Ten and 12 volunteers who completed the Baden-Marathon race in Karlsruhe with a running distance of 21.1 km and 41.195 km, respectively, were assessed 10 days before and immediately after the finish. There was no increase in the levels of endogenous DNA strand breaks immediately after half-marathon or marathon races. A statistically significant increase in the levels of oxidative DNA damage in lymphocytes was found using endonuclease III but not formamidopyrimidine glycolase (Fpg). The resistance of DNA to oxidative damage induced by hydrogen peroxide in isolated lymphocytes was significantly decreased after both races. The levels of plasma antioxidants such as α-tocopherol, β-carotene and lycopene were close to, or higher than, those considered optimal for reducing the risk of cardiovascular diseases and there were no significant changes after the races in antioxidant capacity of LDL (lag-time test) or plasma in ORAC, TEAC or paraoxonase assays. The number and percentage of granulocytes and monocytes able to generate oxidative burst were significantly increased after both races, but the lytic activity of NK cells was significantly increased at the end of the half-marathon; no effect was observed in the marathon runners. Thus, oxidative DNA damage in lymphocytes, decreased the antioxidant capacity to protect lymphocytes against DNA strand breaks and increased the formation of reactive species by phagocytes in well-nourished hobby runners indicating moderate oxidative damage during such high-intensity exercise. Verf.-Referat
abstract_lang eng
abstract_type author
author2 Briviba, Karlis
Watzl, Bernhard
Nickel, Kerstin
Kulling, Sabine
Bös, Klaus
Härtel, Sascha
Rechkemmer, Gerhard
Bub, Achim
author_facet Briviba, Karlis
Watzl, Bernhard
Nickel, Kerstin
Kulling, Sabine
Bös, Klaus
Härtel, Sascha
Rechkemmer, Gerhard
Bub, Achim
author2-role Autor
Autor
Autor
Autor
Autor
Autor
Autor
Autor
author2-authorityid
P166327


P1117
P133269
P157647
P166330
author_author_facet Briviba, Karlis
Watzl, Bernhard
Nickel, Kerstin
Kulling, Sabine
Bös, Klaus
Härtel, Sascha
Rechkemmer, Gerhard
Bub, Achim
author2-synonym







author2_hierarchy_facet 0/Autor/
1/Autor/Briviba, Karlis/
0/Autor/
1/Autor/Watzl, Bernhard/
0/Autor/
1/Autor/Nickel, Kerstin/
0/Autor/
1/Autor/Kulling, Sabine/
0/Autor/
1/Autor/Bös, Klaus/
0/Autor/
1/Autor/Härtel, Sascha/
0/Autor/
1/Autor/Rechkemmer, Gerhard/
0/Autor/
1/Autor/Bub, Achim/
issn 1351-0002
1743-2928
spelling 1351-0002
1743-2928
1305290-1
Desoxyribonukleinsäure
Fallstudie
Freizeitsport
Halbmarathon
Immunsystem
Kapazität, antioxidative
Lymphozyt
Marathonlauf
Sportmedizin
Sportwissenschaft
antioxidant capacity
case study
Deoxyribonucleic acid
half-marathon
immune system
leisure-time sport
lymphocyte
marathon running
sport science
sports medicine
Theorie der Körpererziehung
Theorie der Leibesübungen
Theorie der Leibeserziehung

Läufer
Marathonläufer
Läuferin
Marathontraining
Lauf
Abwehr, körpereigene
Abwehrmechanismus
Erholungssport
Freizeitsportler
Rekreation
Freizeitsportangebot
Freizeitsportprogramm
Freizeitsporttherapie
Recreation
Medizin
Geschichte der Medizin
Untersuchung, sportmedizinische
Wasserdampf
exercise science
sport and exercise science
DNA
immunological system
recreational sport
A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners
PU201108007425
201108007425
zdb 1305290-1
location_hierarchy_facet 0/Großbritannien/
1/Großbritannien/England/
topic Desoxyribonukleinsäure
Fallstudie
Freizeitsport
Halbmarathon
Immunsystem
Kapazität, antioxidative
Lymphozyt
Marathonlauf
Sportmedizin
Sportwissenschaft
topic_facet Desoxyribonukleinsäure
Fallstudie
Freizeitsport
Halbmarathon
Immunsystem
Kapazität, antioxidative
Lymphozyt
Marathonlauf
Sportmedizin
Sportwissenschaft
topic_en antioxidant capacity
case study
Deoxyribonucleic acid
half-marathon
immune system
leisure-time sport
lymphocyte
marathon running
sport science
sports medicine
topic_en_facet antioxidant capacity
case study
Deoxyribonucleic acid
half-marathon
immune system
leisure-time sport
lymphocyte
marathon running
sport science
sports medicine
synonym Theorie der Körpererziehung
Theorie der Leibesübungen
Theorie der Leibeserziehung

Läufer
Marathonläufer
Läuferin
Marathontraining
Lauf
Abwehr, körpereigene
Abwehrmechanismus
Erholungssport
Freizeitsportler
Rekreation
Freizeitsportangebot
Freizeitsportprogramm
Freizeitsporttherapie
Recreation
Medizin
Geschichte der Medizin
Untersuchung, sportmedizinische
Wasserdampf
synonym_en exercise science
sport and exercise science
DNA
immunological system
recreational sport
journal_facet Redox report
container_title Redox report
container_volume 10
container_issue 6
container_start_page S. 325-331
has_references 1
institution BISp
journal_fac JO00000101028
journal_year 2005
journal_issue 6
_version_ 1810304622903951360
score 13,2632065