A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners
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| Deutscher übersetzter Titel: | Ein Halbmarathon- und ein Marathonlauf verursacht oxidative DNS-Schädigung, reduziert die antioxidative Kapazität, die gegen DNS-Schädigungen schützt und verändert die Immunfunktion bei Hobbyläufern |
|---|---|
| Autor: | Briviba, Karlis; Watzl, Bernhard; Nickel, Kerstin; Kulling, Sabine; Bös, Klaus; Härtel, Sascha; Rechkemmer, Gerhard; Bub, Achim |
| Erschienen in: | Redox report |
| Veröffentlicht: | 10 (2005), 6, S. 325-331, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 1351-0002, 1743-2928 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201108007425 |
| Quelle: | BISp |
| id |
PU201108007425 |
|---|---|
| bisp-collection |
db |
| format |
Literatur |
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2011-08-31T11:39:18Z |
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2011-08-31T11:27:51Z |
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BISp |
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Zeitschriftenartikel |
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JO00000101028 |
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JOI200500060101028 |
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Redox report |
| hierarchy_parent_title |
Redox report, 2005, 6 |
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PU201108007425 |
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A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners |
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0325 |
| recordtype |
bisparticle |
| publishDate |
2005 |
| publishDate_facet |
2005 |
| language |
eng |
| title |
A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners |
| spellingShingle |
A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners Desoxyribonukleinsäure Fallstudie Freizeitsport Halbmarathon Immunsystem Kapazität, antioxidative Lymphozyt Marathonlauf Sportmedizin Sportwissenschaft |
| title_sort |
a halfmarathon and a marathon run induce oxidative dna damage reduce antioxidant capacity to protect dna against damage and modify immune function in hobby runners |
| title_short |
A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners |
| title_alt |
Ein Halbmarathon- und ein Marathonlauf verursacht oxidative DNS-Schädigung, reduziert die antioxidative Kapazität, die gegen DNS-Schädigungen schützt und verändert die Immunfunktion bei Hobbyläufern |
| title_alt_lang |
deu |
| media_type |
Gedruckte Ressource |
| city |
Leeds |
| abstract |
This study investigated whether a 21.1 km (half-marathon) or a 42.195 km (marathon) run modulates DNA damage, antioxidant capacity in lymphocytes and plasma, and the immune system in healthy hobby runners. Ten and 12 volunteers who completed the Baden-Marathon race in Karlsruhe with a running distance of 21.1 km and 41.195 km, respectively, were assessed 10 days before and immediately after the finish. There was no increase in the levels of endogenous DNA strand breaks immediately after half-marathon or marathon races. A statistically significant increase in the levels of oxidative DNA damage in lymphocytes was found using endonuclease III but not formamidopyrimidine glycolase (Fpg). The resistance of DNA to oxidative damage induced by hydrogen peroxide in isolated lymphocytes was significantly decreased after both races. The levels of plasma antioxidants such as α-tocopherol, β-carotene and lycopene were close to, or higher than, those considered optimal for reducing the risk of cardiovascular diseases and there were no significant changes after the races in antioxidant capacity of LDL (lag-time test) or plasma in ORAC, TEAC or paraoxonase assays. The number and percentage of granulocytes and monocytes able to generate oxidative burst were significantly increased after both races, but the lytic activity of NK cells was significantly increased at the end of the half-marathon; no effect was observed in the marathon runners. Thus, oxidative DNA damage in lymphocytes, decreased the antioxidant capacity to protect lymphocytes against DNA strand breaks and increased the formation of reactive species by phagocytes in well-nourished hobby runners indicating moderate oxidative damage during such high-intensity exercise. Verf.-Referat |
| abstract_lang |
eng |
| abstract_type |
author |
| author2 |
Briviba, Karlis Watzl, Bernhard Nickel, Kerstin Kulling, Sabine Bös, Klaus Härtel, Sascha Rechkemmer, Gerhard Bub, Achim |
| author_facet |
Briviba, Karlis Watzl, Bernhard Nickel, Kerstin Kulling, Sabine Bös, Klaus Härtel, Sascha Rechkemmer, Gerhard Bub, Achim |
| author2-role |
Autor Autor Autor Autor Autor Autor Autor Autor |
| author2-authorityid |
P166327 P1117 P133269 P157647 P166330 |
| author_author_facet |
Briviba, Karlis Watzl, Bernhard Nickel, Kerstin Kulling, Sabine Bös, Klaus Härtel, Sascha Rechkemmer, Gerhard Bub, Achim |
| author2-synonym |
|
| author2_hierarchy_facet |
0/Autor/ 1/Autor/Briviba, Karlis/ 0/Autor/ 1/Autor/Watzl, Bernhard/ 0/Autor/ 1/Autor/Nickel, Kerstin/ 0/Autor/ 1/Autor/Kulling, Sabine/ 0/Autor/ 1/Autor/Bös, Klaus/ 0/Autor/ 1/Autor/Härtel, Sascha/ 0/Autor/ 1/Autor/Rechkemmer, Gerhard/ 0/Autor/ 1/Autor/Bub, Achim/ |
| issn |
1351-0002 1743-2928 |
| spelling |
1351-0002 1743-2928 1305290-1 Desoxyribonukleinsäure Fallstudie Freizeitsport Halbmarathon Immunsystem Kapazität, antioxidative Lymphozyt Marathonlauf Sportmedizin Sportwissenschaft antioxidant capacity case study Deoxyribonucleic acid half-marathon immune system leisure-time sport lymphocyte marathon running sport science sports medicine Theorie der Körpererziehung Theorie der Leibesübungen Theorie der Leibeserziehung Läufer Marathonläufer Läuferin Marathontraining Lauf Abwehr, körpereigene Abwehrmechanismus Erholungssport Freizeitsportler Rekreation Freizeitsportangebot Freizeitsportprogramm Freizeitsporttherapie Recreation Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf exercise science sport and exercise science DNA immunological system recreational sport A half-marathon and a marathon run induce oxidative DNA damage, reduce antioxidant capacity to protect DNA against damage and modify immune function in hobby runners PU201108007425 201108007425 |
| zdb |
1305290-1 |
| location_hierarchy_facet |
0/Großbritannien/ 1/Großbritannien/England/ |
| topic |
Desoxyribonukleinsäure Fallstudie Freizeitsport Halbmarathon Immunsystem Kapazität, antioxidative Lymphozyt Marathonlauf Sportmedizin Sportwissenschaft |
| topic_facet |
Desoxyribonukleinsäure Fallstudie Freizeitsport Halbmarathon Immunsystem Kapazität, antioxidative Lymphozyt Marathonlauf Sportmedizin Sportwissenschaft |
| topic_en |
antioxidant capacity case study Deoxyribonucleic acid half-marathon immune system leisure-time sport lymphocyte marathon running sport science sports medicine |
| topic_en_facet |
antioxidant capacity case study Deoxyribonucleic acid half-marathon immune system leisure-time sport lymphocyte marathon running sport science sports medicine |
| synonym |
Theorie der Körpererziehung Theorie der Leibesübungen Theorie der Leibeserziehung Läufer Marathonläufer Läuferin Marathontraining Lauf Abwehr, körpereigene Abwehrmechanismus Erholungssport Freizeitsportler Rekreation Freizeitsportangebot Freizeitsportprogramm Freizeitsporttherapie Recreation Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf |
| synonym_en |
exercise science sport and exercise science DNA immunological system recreational sport |
| journal_facet |
Redox report |
| container_title |
Redox report |
| container_volume |
10 |
| container_issue |
6 |
| container_start_page |
S. 325-331 |
| has_references |
1 |
| institution |
BISp |
| journal_fac |
JO00000101028 |
| journal_year |
2005 |
| journal_issue |
6 |
| _version_ |
1810304622903951360 |
| score |
13,263396 |