Abstract

In Übersichts- und Original-Artikeln werden verschiedene Aspekte der Doping-Analytik behandelt. Im Abschnitt I "Blood Analysis - Expectations - Possibilities" werden die Möglichkeiten und Methoden der Dopinganalyse von Blutproben diskutiert. Im Abschnitt II "Steroid Analysis" wird u.a. die Stabilität von Steroid-Profilen besprochen. In Abschnitt III "Detection of Peptide Hormones" finden sich u.a. Beiträge zum HGH-Nachweis. Im Abschnitt IV "Improvement of Analytical Techniques" werden neue Messmethoden vorgestellt. Im Abschnitt V "Organisation of Doping Analysis and Doping Control" finden sich Artikel zur Doping-Analytik während der Olympischen Spiele in Lillehammer 1994 und Barcelona 1992. Die Autoren und ihre Beiträge sind: I. Blood analysis - expectations - possibilities. 1. Birkeland, K.I.; Hemmersbach, P.; Haug, E.: Blood sampling in doping control - which new information may be obtained? 2. Rendic, S.: Binding of anabolic steroids to human serum albumin and possible interactions with other drugs. 3. Horning, S.; Schänzer, W.; Donike, M.: Steroid profiling in human and horse blood: some results. 4. Hornig, S.; Schänzer, W.; Donike, M.: GC/HR MS determination of the serum/plasma testosterone / 17-α-Hydroxyprogesterone ratio and its significance. 5. Torre, X. de la; Segura, J.; Polettini, A.: Detection of testosterone esters in human plasma by GC/MS and GC/MS/MS. 6. Ayotte, C.: Determination of free methyltestosterone in plasma samples. II. Steroid analysis. 7. Schänzer, W.; Donike, M.: Synthesis of deuterated steroids for GC/MS quantification of endogenous steroids. 8. Nolteernsting, E.; Geyer, H.; Mareck-Engelke, U.; Schänzer, W.; Donike, M.: Standardisation of the T/E-determination by deuteral internal standards. 9. Mareck-Engelke, U.; Geyer, H.; Donike, M.: Stability of steroid profiles (4): ratios and excretion rates of endogenous steroids in female urines collected four times over 24 hours. 11. Donike, M.; Mareck-Engelke, U.; Rauth, S.: Statistical evaluation of longitudinal studies, part 2: the usefulness of subject based reference ranges. 12. Seppenwoolde-Waasdorp, T.J.A.; Heeswijk, R.P.G. van; Boer, D. de; Maes, R.A.A.: Evaluation of endogenous steroid profiles in urine (1) - effect of illness and the use of antibiotics. 13. Debruyckere, G.; Sagher, R. de; Peteghem, C. van: Detection of interferences in urinary anabolic steroid analysis. 14. Hemmersbach, P.; Tomten, S.; Nilsson, S.; Oftebro, H.; Havrevoll, O.; Oen, B.; Birkeland, K.: Illegal use of anabolic agents in animal fattening - consequences for doping analysis. 15. Bowers, L.D.: Effect of sulfinpyrazone on urinary secretion of steroid conjugates. 16. Geyer, H.; Mareck-Engelke, U.; Nolteernsting, E.; Opfermann, G.; Donike, M.: The matrix problem in calibration of the GC/MS for endogenous steroids. The search for an artificial urine. 17. Schänzer, W.; Geyer, H.; Gotzmann, A.; Horning, S.; Mareck-Engelke, U.; Nitschke, R.; Nolteernsting, E.; Donike, M.: Endogenous production and excretion of boldenone (17ß-hydroxyandrosta-1,4-dien-3-one), an androgenic anabolic steroid. III. Detection of peptide hormones. 18. Saugy, M.; Cardis, C.; Rivier, L.: Urinary human growth hormone (U-HGH): I. Measurements in non-athlete volunteers after intra-muscular or subcutaneous hGH injections. 19. Saugy, M.; Cardis, C.; Rivier, L.; Brisson, G.; Ayotte, C.; Hemmersbach, P.; Haug, E.; Segura, J.: Urinary human growth hormone (U-HGH): II. Measurements in competition tests: more the expression of the renal function than the endocrinological status. 20. Liu, C.; Bowers, L.D.: Studies toward confirmation of HCG using HPLC/MS. IV. Improvement of analytical techniques. 21. Börnsen, K.O.; Gassmann, E.; Schär, M.; Widmer, H.M.: Matrix assisted laser desorption and ionization - mass spectrometry: a new analytical tool. 22. Herold, M.; Dollekamp, H.; Grimm, R.: Micropreparative peptide separation by capillary electrophoresis. 23. Bowers, L.; Abbott, V.: Evaluation and extraction methods and third generation HPLC columns for analysis of diuretics. 24. Gotzmann, A.; Schänzer, W.; Geyer, H.; Donike, M.: Detection of trenbolone by HPLC. 25. Thieme, D.; Große, J.; Lang, R.; Mueller, R.K.: Detection of mesocarb metabolite by LC - TS/MS. 26. Delbeke, F.T.: A threshold level for theophylline in urine: preliminary results. 27. Breidbach, A.; Sigmund, G.; Donike, M.: Combination of screening procedures - mesocarb detection as an example. 28. Boer, D. de; Ooijen, R.D. van; Maes, R.A.A.: Thermostable derivatives of mesocarb and its p-hydroxy metabolite. 29. Große, J.; Lang, R.; Mueller, R.K.; Thieme, D.: Detection of tamoxifen metabolites in urine by GC/MS. 30. Boer, D. de; Wal, R.M.A. van de; Bos, K.L.; Maes, R.A.A.: Fluoroacyl-(S)-prolyl derivatization for the enantiomeric profiling of 3,4-methylenedioxymetamphetamine, methylphenidate, ephedrines and their major metabolites in urine. 31. Rivier, L.; Saugy, M.: Coca and Cocaine: What can be done in doping analysis. 32. Tsoutsoulova-Draganova, A.: Investigation on products of thiazide diuretics in human urine. 33. Lisi, A.; Kazlauskas, R.; Trout, G.; Nolteernsting, E.; Donike, M.: Buprenorphine by GC-MS after derivatization by direct extractive alkylation. 34. Ayotte, C.; Charlebois, A.; Goudreault, D.; Lévesque, C.: Improvements of drug detection and analysis by appropriate preparation of the injection port of the gas chromatograph. V. Organisation of doping analysis and doping control. 35. Hemmersbach, P.; Bjerke, B.; Birkeland, K.; Haug, E.: Short report from the doping analysis during the XVII Olympic Winter Games. 36. Segura, J.; Torre, R. de la; Pascual, J.A.; Ventura, R.; Farré, M.; Ewin, R.R.; Cami, J.: Antidoping control laboratory at the games of the XXV Olympiad Barcelona'92. Part I. Management of resources. 37. Segura, J.; Torre, R. de la; Pascual, J.A.; Ventura, R.; Farré, M.; Ewin, R.R.; Cami, J.: Antidoping control laboratory at the games of the XXV Olympiad Barcelona'92. Part II. Strategies and results. 38. Bruunshuus, I.; Cowan, D.; Hill, G.; Olesen, H.: Quantities and units in drugs of abuse.