Study of the behavior of the steroid profile under hydrolysis conditions after 4-androstenedione oral administration by GC/MS
| Deutscher übersetzter Titel: | Die Untersuchung des Verhaltens von Steroidprofilen unter Hydrolysebedingungen nach der oralen Gabe von 4-Androstenedion mittels GC/MS |
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| Autor: | Abidi, M.; Karkeni, S.; Ben Hamida, N.; Toumi, A. |
| Erschienen in: | Recent advances in doping analysis (14) : Proceedings of the Manfred Donike Workshop ; 24th Cologne Workshop on Dope Analysis ; 4th to 9th June 2006 |
| Veröffentlicht: | Köln: Sportverl. Strauß (Verlag), 2006, S. 407-410, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201001000268 |
| Quelle: | BISp |
Abstract
Androstenedione(4-androstene-3,17-dione) is secreted endogenously by the adrenal cortex and the gonads, and the small amount is also produced by peripheral conversion. It is an immediate precursor to testosterone in the intrinsic synthetical pathways of androgens. The evaluation of urine steroid profile under normal procedure used for anabolic steroids (1 hour at 55°C) compared to the hydrolysis for about 15 hours at 37°C has been suggested. This change affects several endogenous compounds such as Testosterone, Epitestosterone, Androsterone, Etiocholanolone, 6α-hydroxyandrostenedione, DHEA, DHT, 5α diol, 5ß diol, OHA, OHE, Pregnanediol, Pregnanetriol and 16(5α)-androsten-3α-ol. In this study, we expose the results obtained after oral administration of 4- androstenedione and the impact on the steroid profile under different conditions of hydrolysis in terms of concentrations to allow the analysis by GC/IRMS according the TD2004EAAS. Einleitung (geändert)