TY  - COLL
AU  - Thevis, Mario
A2  - Thevis, Mario
A2  - Horning, Stevan
A2  - Makarov, Alexander A.
A2  - Schänzer, Wilhelm
DB  - BISp
DP  - BISp
KW  - Biochemie
KW  - Doping
KW  - Dopingnachweis
KW  - Flüssigkeitschromatographie
KW  - Leistungssport
KW  - Leistungssteigerung
KW  - Massenspektrometrie
KW  - Messverfahren
KW  - Sportmedizin
KW  - Steroid
KW  - Untersuchungsmethode
LA  - eng
PB  - Sportverl. Strauß
CY  - Köln
TI  - Mass spectrometric characterization of efaproxiral (RSR13) and stanozolol using electrospray ionization with high resolution/high accuracy mass spectrometry
TT  - Die massenspektrometrische Bestimmung von Efaproxiral (RSR13) und Stanozolol mittels Electrospray-Ionisation mit hochauflösender/Hochpräzisionsmassenspektrometrie
PY  - 2006
N2  - In the present study the collision-induced dissociation (CID) behavior of efaproxiral (RSR13) and stanozolol employing an LTQ-Orbitrap mass spectrometer with high resolution/high accuracy and MSn capabilities is shown, which allows the assignment of diagnostic product ions to defined regions of investigated molecules. Modifications of these structures would result in distinct shifts of characteristic product ions providing evidence for either metabolic alteration or intentional chemical manipulation of drugs. Both facts would be of utmost importance for doping control analysis to uncover surreptitious administrations of these drugs or related substances. The structural elucidation of drugs relevant for doping controls by tandem mass spectrometry concerted with MSn capabilities and high resolution-high accurate mass measurement provides information that can be utilized to identify further unknown metabolites or artificially modified analogues. Recent discoveries of synthetic growth promoters on the basis of so-called designer steroids has urged sports drug testing laboratories to extend screening procedures and develop complementary assays that allow a comprehensive detection of compounds with closely related structures to known therapeutic agents. Here, detailed knowledge of mass spectral behavior of target analytes is of great importance as well as for unambiguous identification of known therapeutics in routine screening analysis. Aus dem Text (geändert)
L2  - https://www.bisp-surf.de/dokumente/Doping_Analysis/2006/articles/pp239-247.pdf
SP  - S. 239-247
BT  - Recent advances in doping analysis (14) : Proceedings of the Manfred Donike Workshop ; 24th Cologne Workshop on Dope Analysis ; 4th to 9th June 2006
M3  - Elektronische Ressource (online)
M3  - Gedruckte Ressource
ID  - PU201001000240
ER  -