Acute effect of physical exercise on serum insulin-like growth factor-binding protein 2 and 3 in healthy men : role of exercise-linked growth hormone secretion

Gespeichert in:
Bibliographische Detailangaben
Deutscher übersetzter Titel:Akute Auswirkung koerperlicher Belastung auf die IGF-I-bindenden Proteine 2 und 3 bei gesunden Maennern : Bedeutung der belastungsbedingten Sekretion des Wachstumshormons
Autor:DiLuigi, L.; Guidetti, L.; Nordio, M.; Baldari, C.; Romanelli, F.
Erschienen in:International journal of sports medicine
Veröffentlicht:22 (2001), 2, S. 103-110, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Gedruckte Ressource Elektronische Ressource (online)
Sprache:Englisch
ISSN:0172-4622, 1439-3964
DOI:10.1055/s-2001-11365
Schlagworte:
Online Zugang:
Erfassungsnummer:PU199912501135
Quelle:BISp

Abstract des Autors

The purpose of this study was to delineate the role of GH on serum IGF-I, IGFBP-2 and -3 responses to exercise. Hormones were evaluated in six trained male subjects before (-30, -15, 0), during (+15) and after (+30, +45, +60, +90 min) a thirty-minutes treadmill exercise (60% VO2max), both after a single administration of a somatostatin analog (i.e., octreotide, 0.1 mg sc) and after saline. The same evaluations were performed without exercise with similar treatments. The results showed that: 1) octreotide significantly inhibited the GH response to exercise, 2) exercise increased IGFBP-3 concentration (+37.4% at +90, p<0.05), whereas no modification of IGFBP-2 and of IGF-I/IGFBP-2 and IGFBP-3/IGFBP-2 ratios were observed, 3) octreotide amplified the IGFBP-3 increase after exercise (p<0.01 vs. exercise, from +30 to +60, or octreotide alone) and, without exercise, slightly increased IGFBP-3 (+15% at +75, p<0.05) and decreased IGF-I (-14.8% at +75, p<0.01). We concluded that GH has a reduced role, as a stimulating factor, in the serum acute IGFBP-3 increase after exercise and that octreotide is probably able to directly amplify this response. Unfortunately, we can only speculate on the physiological pathways involved. Verf.-Referat