Abstract des Autors

Purpose: The objectives of this study were twofold: 1) to determine the effect of incremental exercise to volitional fatigue on plasma levels of lipid peroxidation (malondialdehyde) in heart transplant recipients (HRT) and 2) to examine blood antioxidant capacity in HTR by assessment of antioxidant enzyme activities and vitamin E levels. Methods: Seven endurance-trained HTR (mean+/-SD; age 39.7+/-12.8 yr) and seven endurance-trained healthy, age-matched control subjects (HC) (mean age 40.6+/-10.7 yr) performed a symptom-limited incremental exercise test on a cycle ergometer. Venous blood samples were obtained at rest, exercise, and during recovery and analyzed for plasma levels of malondialdehyde (MDA) as well as markers of blood antioxidant capacity. After exercise and during recovery, all dependent measures were corrected for plasma volume changes induced by exercise. Significance was established at (P<0.05). Results: No group differences existed in plasma levels of MDA at rest. Further, graded exercise did not alter plasma levels of MDA in either group. Resting erythrocyte glutathione peroxidase (GPX) activity was significantly lower and erythrocyte superoxide dismutase (SOD) activity was higher in HTR compared with HC. Finally, at rest, no group differences existed in plasma GPX activity or vitamin E levels. Conclusions: Graded exercise to fatigue does not promote an increase in oxidative stress in blood of exercise trained HTR. Therefore, physical exercise does not appear to pose an oxidative-stress risk for these patients. Verf.-Referat