Acute amino acids supplementation enhances pituitary responsiveness in athletes
Deutscher übersetzter Titel: | Aminosaeuren-Supplementierung erhoeht die Reaktionsbereitschaft der Hypophyse bei Sportlern |
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Autor: | DiLuigi, L.; Guidetti, L.; Pigozzi, F.; Baldari, C.; Casini, A.; Nordio, M.; Romanelli, F. |
Erschienen in: | Medicine and science in sports and exercise |
Veröffentlicht: | 31 (1999), 12, S. 1748-1754, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0195-9131, 1530-0315 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199912404555 |
Quelle: | BISp |
Abstract des Autors
Purpose: The purpose of this study was to determine the effect of a mixture of amino acids on pituitary responsiveness to a stimulation test (GnRH + CRH) in athletes. Methods: In a double blinded counterbalanced experimental protocol, 10 moderately trained male athletes performed the pituitary stimulation test 60 min after a single oral administration of a placebo (PI-AS) or an amino acid mixture solution (AS) (L-arginine hydrocloride 100 mg/kg + L-ornithine hydrocloride 80 mg/kg + L-branched chain amino acids 140 mg/kg: 50% L-leucine, 25% L-isoleucine, 25% L-valine) on two different occasions. Plasma ACTH, LH, FSH, GH, and cortisol were evaluated before (-60, -30, 0 min) and after (+15, +30, +45, +60, +90 min) the stimulation test. Results: The ACTH, LH and FSH response to CRH + GnRH was significantly higher in AS group both as absolute values and area under curve (AUC) values than in PI-AS group. Pre-test and post-test cortisol AUC levels were significantly higher in PI-AS group although a higher percent increase in post-test cortisol was found in AS group. The total GH-AUC was higher in AS group and, as expected, the absolute GH concentrations at different time points were not influenced by CRH + GnRH administration. Conclusion: The amino acid mixture used enhanced the ACTH, LH, and FSH response to CRH + GnRH. Verf.-Referat