Abstract des Autors

The effect of a single bout of mild exercise on glucose effectiveness (SG) and insulin sensitivity (SI) was studied in six young male subjects by using a minimal model. An intravenous glucose tolerance test was performed under two conditions as follows: 1) 25 min after a bout of exercise on a cycle ergometer at the lactate threshold level for 60 min (Ex) and 2) without any prior exercise (Con). Leg blood flow (LBF) was also measured by strain-gauge plethysmography simultaneously with blood sampling. SI did not significantly change after exercise (18.1+/-1.5 vs. 17.7+/-1.9 x 10**-5, min/pM), whereas SG significantly increased (0.016+/-0.002 vs. 0.025+/-0.002/min, P<0.01). The increased blood flow after exercise remained high during the time period for measurement of the glucose disappearance constant and may be a determinant of SG. The incremental lactate area under the curve until insulin loading was also significantly higher in Ex than in Con (2.6+/-0.9 vs. -3.5+/-1.5 mM/min, P<0.05). These results suggest that increased SG after mild exercise may be due, at least in part, to increased LBF and lactate production under a hyperglycemic state. Verf.-Referat