Abstract des Autors

Postflight orthostatic intolerance is experienced by virtually all astronauts but differs greatly in degree of severity. We studied cardiovascular responses to upright posture in 40 astronauts before and after spaceflights lasting up to 16 days. We separated individuals according to their ability to remain standing without assistance for 10 min on landing day. Astronauts who could not remain standing on landing day had significantly smaller increases in plasma norepinephrine levels with standing than did those who could remain standing (105+/-41 vs. 340+/-62 pg/ml; P=0.05). In addition, they had significantly lower standing peripheral vascular resistance and greater decreases in systolic and diastolic pressures. The presyncopal group also had significantly lower supine and standing vascular resistance, supine and standing diastolic pressure, and supine and standing systolic pressures before flight. This is the first study to clearly document these differences among presyncopal and nonpresyncopal astronauts after spaceflight and also offer the possibility of preflight prediction of postflight susceptibility. These results clearly point to hyperadrenergic responsiveness, possibly centrally mediated, as a contributing factor in postflight orthostatic intolerance. They may provide insights into autonomic dysfunction in Earthbound patients. Verf.-Referat