Effect of intravenous L-carnitine on carnitin homeostasis and fuel metabolism during exercise in humans
Deutscher übersetzter Titel: | Auswirkung intravenoeser L-Karnitin-Injektion auf die Karnitinhomoeostase und den Energiestoffwechsel unter koerperlicher Belastung beim Menschen |
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Autor: | Brass, Eric P.; Hoppel, Charles L.; Hiatt, William R. |
Erschienen in: | Clinical pharmacology and therapeutics |
Veröffentlicht: | 55 (1994), 6, S. 681-692, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0260-0099 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199611201274 |
Quelle: | BISp |
Abstract des Autors
This study was undertaken to challenge the hypothesis that short-term administration of carnitine during exercise can modify skeletal muscle carnitine homeostasis and fuel metabolism in normal humans. With a randomized, blinded, crossover design, subjects received carnitine or placebo at the start of a bicycle ergometer exercise session. During the 2 hours after intravenous administration of 185 micro-mol/kg carnitine, carnitine kinetics could be described with a central compartment volume of distribution of 200 ml/kg, a total clearance from this compartment of 1.9 ml/min/kg, and a renal clearance of 1.3 ml/min/kg. Carnitine administration had no effect on muscle total carnitine content or the workload-dependent accumulation of acylcarnitines in skeletal muscle. Carnitine had no effect on the respiratory exchange ratio, muscle lactate accumulation, plasma lactate concentration, muscle glycogen utilization, or plasma beta-hydroxybutyrate concentration during exercise. Thus the skeletal muscle carnitine pool is segregated from dramatic changes in the plasma carnitine pool, and short-term administration of carnitine has no significant effect on fuel metabolism during exercise in humans. Verf.-Referat