Exercise-induced alterations in natural killer cell number and function
Deutscher übersetzter Titel: | Durch körperliche Belastung induzierte Änderungen von Zahl und Funktion der natürlichen Killerzellen |
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Autor: | Moyna, Niall M.; Acker, Gwendolyn R.; Weber, Kelly M.; Fulton, Jonathan R.; Robertson, Robert J.; Goss, Fredric L.; Rabin, Bruce S. |
Erschienen in: | European journal of applied physiology |
Veröffentlicht: | 74 (1996), 3, S. 227-233, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 1439-6319, 0301-5548 |
DOI: | 10.1007/BF00377445 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199610200721 |
Quelle: | BISp |
Abstract des Autors
To study the effects of exercise on natural killer (NK) cell number and activity (NKCA) healthy male (n=32) and female (n=32) subjects were randomly assigned to an exercise or control condition. Exercise involved a continuous incremental protocol consisting of cycling for three periods of 6 min at work rates corresponding to 55%, 70% and 85% peak oxygen uptake (VO2peak). Blood samples were drawn at baseline, at 6 min, 12 min and 18 min during exercise, and at 2 h following completion of exercise. Relative to both baseline and control conditions, exercise resulted in an increase in the number of circulating lymphocytes. The proportion of T cells (CD3+) and B cells (CD19+) significantly decreased, and NK cells (CD3- CD16+ CD56+) increased throughout exercise. NKCA increased during the initial 6 min of exercise with no further changes observed, despite increases in the number and proportion of circulating NK cells during exercise at 70% and 85% VO2peak. Plasma epinephrine and norepinephrine increased above baseline at 12 min and 18 min. The changes in NK cell number and function were independent of gender. The results indicate that short-duration low-intensity exercise can significantly increase NK cell number and activity. However, alterations in NK cell number are not accompanied by changes of a similar magnitude in NKCA. Verf.-Referat