Abstract des Autors

The study investigated the influence of prolonged physical stress during survival training with food and fluid deprivation on the serum concentrations of erythropoietin (EPO). A group of 29 male subjects (age 22.2(SD 2.8) years, height 1.78(SD 0.06) m, and body mass (mb) 73.5(SD 8.6) kg) were studied for 5 days of multifactorial stress including restricted water intake (1 l H2O/day) and food intake (628 kJ/day) combined with physical exercise (estimated energy expenditure approximately 24 000 kJ/day) and sleep deprivation (20 h within 5 days). Blood samples were taken before (T1), after 72 h (T2) and 120 h (T3) of physical stress, and after 48 h, (T4) and 72 h (T5) of recovery. The samples were analysed for EPO, and concentrations of serum iron (Fe), haptoglobin (Hapto), transferrin (Trans), ferritin (Fer), haemoglobin (Hb) and packed cell volume (PCV). The mb had decreased by 6,77 kg at T3 and 0.68 kg at T5. The EPO and Hapto decreased during the survival training and increased during the recovery period. The Fe increased during the survival training and remained above the control concentrations during recovery. The Hapto decreased during the survival training and remained below control concentration at T4 and T5. The Trans decreased continuously over the week. The Fer increased during the survival training and returned to control concentration at T5. The Hb increased from T1 to T2 and had decreased significantly at T5. The PCV increased from T1 to T2 and remained below control levels afterwards. From our study it was concluded that, in humans, prolonged physical stress with food and fluid deprivation induces a marked EPO decrease, which is followed by a rapid increase during recovery to restore the reduced O2 transport capacity. Verf.-Referat