Rat skeletal muscle metabolism in experimental heart failure: effects of physical training
Gespeichert in:
| Deutscher übersetzter Titel: | Skelettmuskelstoffwechsel von Ratten bei experimentell induzierter Herzinsuffizienz: Auswirkungen von koerperlichem Training |
|---|---|
| Autor: | Brunotte, F.; Thompson, C.H.; Adamopoulos, S.; Coats, A.; Unitt, J.; Lindsay, D.; Kaklamanis, L.; Radda, G.K.; Rajagopalan, B. |
| Erschienen in: | Acta physiologica Scandinavica |
| Veröffentlicht: | 154 (1995), 4, S. 439-447, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 0001-6772, 1365-201X |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU199603106712 |
| Quelle: | BISp |
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PU199603106712 |
|---|---|
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db |
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Literatur |
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2008-05-13T12:42:38Z |
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2001-07-24T13:27:46Z |
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BISp |
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Zeitschriftenartikel |
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JO00000000032 |
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JOI199500040000032 |
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Acta physiologica Scandinavica |
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Acta physiologica Scandinavica, 1995, 4 |
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PU199603106712 |
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Rat skeletal muscle metabolism in experimental heart failure: effects of physical training |
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0439 |
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bisparticle |
| publishDate |
1995 |
| publishDate_facet |
1995 |
| language |
eng |
| title |
Rat skeletal muscle metabolism in experimental heart failure: effects of physical training |
| spellingShingle |
Rat skeletal muscle metabolism in experimental heart failure: effects of physical training Gesundheitswert Herzinfarkt Herzinsuffizienz Koronarrehabilitation Kreatinphosphat Magnetresonanztomographie Muskelenzym Muskelstoffwechsel pH-Wert Skelettmuskulatur Spektroskopie Sportmedizin Tierversuch Training, rehabilitatives Trainingswirkung |
| title_sort |
rat skeletal muscle metabolism in experimental heart failure effects of physical training |
| title_short |
Rat skeletal muscle metabolism in experimental heart failure: effects of physical training |
| title_alt |
Skelettmuskelstoffwechsel von Ratten bei experimentell induzierter Herzinsuffizienz: Auswirkungen von koerperlichem Training |
| title_alt_lang |
deu |
| media_type |
Gedruckte Ressource |
| city |
Stockholm |
| abstract |
Skeletal muscle metabolic abnormalities exist in chronic heart failure. The influence of physical training on muscle metabolism after myocardial infarction was studied in a rat model. 31P magnetic resonance spectroscopy and enzyme assays were performed in Wistar rats 12 weeks after coronary artery ligation. Infarcted rats were allocated randomly to either 6 weeks of training or non-training. Spectra were collected from the calf muscles during sciatic nerve stimulation at 2 Hz. Fibre typing and enzymatic assays were performed on the muscles of the contralateral non stimulated leg. Post-mortem rats were also divided into severe and moderate heart failure according to the lung weight per body weight. At 200 g twitch tension, phosphocreatine and pH were found to be significantly lower in the non-trained severe heart failure group compared with the other groups. Phosphocreatine recovery half-time was significantly longer in the non-trained group with severe heart failure and correlated with the citrate synthase activity in the muscle. The training did not induce a change in the enzyme activities in the infarcted animals with moderate heart failure but did correct the lower citrate synthase activity in the non-trained severe heart failure animals. This normalization of muscle metabolism was achieved by training without any change in calf muscle mass, making atrophy unlikely to be the sole cause of the metabolic changes in heart failure. Training in rats with severe heart failure can reverse the abnormalities of skeletal muscle metabolism, implicating decreased physical activity in the aetiology of these changes. Verf.-Referat |
| abstract_lang |
eng |
| abstract_type |
author |
| author2 |
Brunotte, F. Thompson, C.H. Adamopoulos, S. Coats, A. Unitt, J. Lindsay, D. Kaklamanis, L. Radda, G.K. Rajagopalan, B. |
| author_facet |
Brunotte, F. Thompson, C.H. Adamopoulos, S. Coats, A. Unitt, J. Lindsay, D. Kaklamanis, L. Radda, G.K. Rajagopalan, B. |
| author2-role |
Autor Autor Autor Autor Autor Autor Autor Autor Autor |
| author2-authorityid |
|
| author_author_facet |
Brunotte, F. Thompson, C.H. Adamopoulos, S. Coats, A. Unitt, J. Lindsay, D. Kaklamanis, L. Radda, G.K. Rajagopalan, B. |
| author2-synonym |
|
| author2_hierarchy_facet |
0/Autor/ 1/Autor/Brunotte, F./ 0/Autor/ 1/Autor/Thompson, C.H./ 0/Autor/ 1/Autor/Adamopoulos, S./ 0/Autor/ 1/Autor/Coats, A./ 0/Autor/ 1/Autor/Unitt, J./ 0/Autor/ 1/Autor/Lindsay, D./ 0/Autor/ 1/Autor/Kaklamanis, L./ 0/Autor/ 1/Autor/Radda, G.K./ 0/Autor/ 1/Autor/Rajagopalan, B./ |
| issn |
0001-6772 1365-201X |
| spelling |
0001-6772 1365-201X APSCA 101-6 Gesundheitswert Herzinfarkt Herzinsuffizienz Koronarrehabilitation Kreatinphosphat Magnetresonanztomographie Muskelenzym Muskelstoffwechsel pH-Wert Skelettmuskulatur Spektroskopie Sportmedizin Tierversuch Training, rehabilitatives Trainingswirkung animal experiment cardiac infarction cardiac insufficiency coronary rehabilitation health value magnetic resonance tomography muscle enzyme muscle metabolism phosphocreatine pH value rehabilitative training skeletal muscles spectroscopy sports medicine training effect Herzkrankheit, ischämische Herzversagen Koronarinsuffizienz Myokardinsuffizienz Aorteninsuffizienz Zyanose Trainingseffekt Trainingserfolg Myokardinfarkt Infarkttherapie KP Rehabilitationstraining Infarktrehabilitation Muskulatur Skelettmuskel Muskel Maus Ratte Tierexperiment Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf heart failure myocardial infarction magnetic resonance imaging Rat skeletal muscle metabolism in experimental heart failure: effects of physical training PU199603106712 199603106712 |
| coden |
APSCA |
| zdb |
101-6 |
| location_hierarchy_facet |
0/Schweden/ |
| topic |
Gesundheitswert Herzinfarkt Herzinsuffizienz Koronarrehabilitation Kreatinphosphat Magnetresonanztomographie Muskelenzym Muskelstoffwechsel pH-Wert Skelettmuskulatur Spektroskopie Sportmedizin Tierversuch Training, rehabilitatives Trainingswirkung |
| topic_facet |
Gesundheitswert Herzinfarkt Herzinsuffizienz Koronarrehabilitation Kreatinphosphat Magnetresonanztomographie Muskelenzym Muskelstoffwechsel pH-Wert Skelettmuskulatur Spektroskopie Sportmedizin Tierversuch Training, rehabilitatives Trainingswirkung |
| topic_en |
animal experiment cardiac infarction cardiac insufficiency coronary rehabilitation health value magnetic resonance tomography muscle enzyme muscle metabolism phosphocreatine pH value rehabilitative training skeletal muscles spectroscopy sports medicine training effect |
| topic_en_facet |
animal experiment cardiac infarction cardiac insufficiency coronary rehabilitation health value magnetic resonance tomography muscle enzyme muscle metabolism phosphocreatine pH value rehabilitative training skeletal muscles spectroscopy sports medicine training effect |
| synonym |
Herzkrankheit, ischämische Herzversagen Koronarinsuffizienz Myokardinsuffizienz Aorteninsuffizienz Zyanose Trainingseffekt Trainingserfolg Myokardinfarkt Infarkttherapie KP Rehabilitationstraining Infarktrehabilitation Muskulatur Skelettmuskel Muskel Maus Ratte Tierexperiment Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf |
| synonym_en |
heart failure myocardial infarction magnetic resonance imaging |
| journal_facet |
Acta physiologica Scandinavica |
| container_title |
Acta physiologica Scandinavica |
| container_volume |
154 |
| container_issue |
4 |
| container_start_page |
S. 439-447 |
| has_references |
1 |
| institution |
BISp |
| journal_fac |
JO00000000032 |
| journal_year |
1995 |
| journal_issue |
4 |
| _version_ |
1791517606198378496 |
| score |
13,560151 |