Lymphocyte subpopulations and concentrations of soluble CD8 and CD4 antigen after anaerobic training
Deutscher übersetzter Titel: | Lymphozytensubpopulationen und Konzentrationen loeslicher CD8- und CD4-Antigene nach anaerobem Training |
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Autor: | Weiss, C.; Kinscherf, R.; Roth, S.; Friedmann, B.; Fischbach, T.; Reus, J.; Droege, W.; Bärtsch, Peter |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 16 (1995), 2, S. 117-121, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-2007-972976 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199509102844 |
Quelle: | BISp |
Abstract des Autors
In 13 middle-aged, moderately trained men (40-60 yr) we investigated the influence of anaerobic training on immunological parameters measured at rest. The 4 week anaerobic training program (two 30-min sessions weight lifting and one interval training per week; lactate levels 4-6 mM and 8-10 mM, respectively), caused a significant increase of the mean arm muscle force by 7% (handgrip test, p<0.05). Evaluation of lymphocyte subsets was performed by means of three-colour immunofluorescence analysis (FACS). After 4 weeks of training we found a significant reduction of the CD4+ T-cell counts by 15% (p<0.05) paralleled by a fall of naive cells (CD3+/CD4+/CD45RA+) by 16%, which, however, was statistically not significant. While percentages of CD3+ lymphocytes decreased significantly by 6% (p<0.001), absolute numbers of CD3+ T-lymphocytes were not detectably affected and also the relative ratio of CD8+ T-cell subsets, i.e. the ratio of suppressor vs cytoxic T-cells (ïCD3+/CD8+/CD11b+, CD3+/CD8+/CD11b- respectively) remained unchanged. Likewise the serum concentrations of the soluble CD8 and CD4 antigen (sCD8/sCD4) as determined by sandwich enzyme immunoassays were found to be unaffected. We conclude that 40-60 years old healthy human subjects performing anaerobic training experience on average a significant decrease of circulating CD4+ T-lymphocytes, while other parameters including the activation parameters sCD8 and sCD4 remain unchanged. Verf.-Referat