Exercise training does not alter cytochrome P-450 content and microsomal metabolism
| Deutscher übersetzter Titel: | Ausdauertraining aendert den Cytochrom P-450-Gehalt und den mikrosomalen Stoffwechsel nicht |
|---|---|
| Autor: | Michaud, T.J.; Bachmann, K.A.; Andres, F.F.; Flynn, M.G.; Sherman, G.P.; Rodriguez-Zayas, J. |
| Erschienen in: | Medicine and science in sports and exercise |
| Veröffentlicht: | 26 (1994), 8, S. 978-982, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 0195-9131, 1530-0315 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU199507101970 |
| Quelle: | BISp |
Abstract des Autors
The purpose of this investigation was to determine whether increased endurance exercise capacity alters total hepatic cytochrome P-450 content and cytochrome P-450 (CYP1A and CYP2B) mediated hepatic microsomal mixed-function oxidase drug metabolism. Twenty adult male Sprague-Dawley rats were randomly assigned to either a control (C) or an endurance trained group (ET). ET rats were progressively trained 5 d/wk for 11 wk. Both C and ET rats were administered in random order single posttraining doses of probe drugs theophylline (probe for CYP1A) and antipyrine (probe for CYP2B). Soleus muscle citrate synthase activity of ET rats was significantly greater than for C rats. In contrast, total liver cytochrome P-450 content was not significantly different among C and ET rats. Likewise, the posttraining C and ET single-sample plasma clearances of theophylline and antipyrine were not significantly different. Therefore it was concluded that strenuous endurance training of 11 wk duration did not alter total hepatic cdytochrome P-450 content or CYP1A or CYP2B activity. Verf.-Referat