Oxidative stress induced by intermittent exposure at a simulated altitude of 4000 m decreases mitochondrial superoxide dismutase content in soleus muscle of rats
Deutscher übersetzter Titel: | Durch intermittierende simulierte Höhenexposition von 4000 m verursachter oxidativer Stress vermindert im M. soleus der Ratte den Gehalt an mitochondrialer Superoxiddismutase |
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Autor: | Radak, Z.; Lee, K.; Choi, W.; Sunoo, S.; Kizaki, T.; Oh-ischi, S.; Suzuki, K.; Taniguchi, N.; Ohno, H.; Asano, K. |
Erschienen in: | European journal of applied physiology |
Veröffentlicht: | 69 (1994), 5, S. 392-395, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 1439-6319, 0301-5548 |
DOI: | 10.1007/BF00865401 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199505076518 |
Quelle: | BISp |
Abstract des Autors
The effects were examined of 6-month intermittent hypobaric (4000 m) exposure on the antioxidant enzyme systems in soleus and tibialis muscles of rats. At the end of the 6-month experimental exposure, the six rats in both the exposed group and the control group were sacrificed. Immunoreactive mitochondrial superoxide dismutase (Mn-SOD) contents were measured as well as the activities of antioxidant enzymes (Mn-SOD, cytosolic SOD (Cu,Zn-SOD), catalase (CAT), and glutathione peroxidase (GPX)). Thiobarbituric acid-reactive substances (TBARS) were also determined as an indicator of lipid peroxidation. The high altitude exposure resulted in a marked increase in TBARS content in soleus muscle, suggesting increased levels of oxygen free radicals. Conversely, significant decreases in both Mn-SOD content and activity in soleus muscle were noted after exposure. Such trends were not noticed in tibialis muscle. On the other hand, no significant changes in CU,Zn-SOD, CAT, or GPX were observed in either muscle. These results suggested that the increases in lipid peroxidation were most probably a result of decreased Mn-SOD function which was more depressed in oxidative than in glycolytic muscle. Verf.-Referat