Effect of long-distance running on polymorphonuclear neutrophil phagocytic function of the upper airways

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Bibliographic Details
Title translated into German:Auswirkung von Langstreckenlauf auf die phagozytaere Funktion der polymorphkernigen Neutrophilen im Respirationstrakt
Author:Muens, G.
Published in:International journal of sports medicine
Published:15 (1994), 2 , S. 96-99, Lit.
Format: Publications (Database SPOLIT)
Publication Type: Journal article
Media type: Print resource
Language:English
ISSN:0172-4622, 1439-3964
Keywords:
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Identification number:PU199408071461
Source:BISp

Abstract

A high incidence of infections predominantly of the upper and lower repsiratory tract have been observed for years after strenuous exercise. The mucosal surfaces represent a first-line-of-defense for airborne pathogens, but little is known about their function during exercise. The purpose of this study was thus to assess the influence of long-distance running on polymorphonuclear neutrophils (PMNs) phagocytic function of the upper respiratory tract. A 20 km race resulted in a 2.0-fold higher count of PMNs in the nasal lavage fluid of 12 male amateur runners (aged 34 +/- 11.3 years) immediately after the competition and a 1.6-fold higher count 1 day after the race in comparison to the pre-race value. During training (7 and 3 days before the race) and after 3 days of recreation (3 days after the race) the runners' counts were lower than immediately after the race. The percentage of phagocytizing PMNs was significantly reduced during the pre-race period, but the reduction was most striking immediately and 1 day after the race. The number of bacteria ingested by the athletes' phagozytizing PMNs was 3.2 +/- 0.3 E. coli/PMN immediately after the race and 5.2 +/- 0.3 1 day after the competition. The findings suggest chronic upper airway inflammation and impaired phagocyte function after strenuous exercise. This might contribute to the observed high incidence of respiratory tract infections among participants in sports. Verf.-Referat (gekuerzt)