TY  - JOUR
AU  - Haas, G.
A2  - Haas, G.
A2  - Hinghofer-Szalkay, H.
A2  - Baisch, F.
A2  - Maass, H.
A2  - Lane, L.
A2  - Blomqvist, C.G.
DB  - BISp
DP  - BISp
KW  - Bettruhe
KW  - Blut
KW  - Blutplasma
KW  - Blutviskosität
KW  - Flüssigkeitsaufnahme
KW  - Flüssigkeitshaushalt
KW  - Hämatokrit
KW  - Körperlage
KW  - Orthostase
KW  - Raumfahrtmedizin
KW  - Sportmedizin
LA  - eng
TI  - Effect of head-down bedrest on blood/plasma density after intravenous fluid load
TT  - Auswirkung einer Bettruhe mit dem Kopf nach unten auf die Blut-/Plasmadichte nach intravenoeser Fluessigkeitszufuhr
PY  - 1992
N2  - Using the mechanical oscillator technique, the mass density of antecubital venous blood and plasma samples was measured in 6 men before and after infusion of 22 ml/kg isotonic NaCl solution before, on day 7 during, and on day 3 after ten days of 6 degrees head-down bedrest. We studied 1) the distribution volumes of the infused NaCl solution, 2) the magnitude and time-course of induced fluid shifts to the extravascular spaces after rapid volume expansion, and 3) the protein concentration of the translocated fluid. The NaCl distribution volume was 16.7 +/- 2.9 body weight (BW) before, 15.0 +/- 3.0 BW during and 13.0 +/- 1.3 BW after the head-down tilt (HDT) period. The volume of fluid shifted 120 min after infusion was not different in the control (12.9 +/- 7.4 plasma volume and 8.3 +/- 3.2 blood volume), during HDT (14.7 +/- 3.8 plasma volume and 7.4 +/- 5.6 blood volume), and after HDT conditions (14.6 +/- 2.2 plasma volume, and 8.2 +/- 1.3 blood volume, respectively). The density of the shifted fluid which reflects protein concentration was also unchanged (1004.2 +/- 4.2 g/l, 1002.6 +/- 4.3 g/l and 1003.9 +/- 8.2 g/l in the control, during, and after HDT periods, respectively). The mass density of red cells did not change with any condition. It is concluded that the distribution volume of isotonic saline solution decreases with diminished body mass. Densitometry provides a means of monitoring volume changes and protein shifts under the cirumstances of our study. Verf.-Referat
SP  - S. 113-120
SN  - 0001-6772
JO  - Acta physiologica Scandinavica
IS  - Suppl. 604
VL  - 144
M3  - Gedruckte Ressource
ID  - PU199405055997
ER  -