Changes in high-energy phosphates in rat skeletal muscle during acute respiratory acidosis
Gespeichert in:
| Deutscher übersetzter Titel: | Konzentrationsaenderungen der energiereichen Phosphate im Skelettmuskel der Ratte bei akuter respiratorischer Azidose |
|---|---|
| Autor: | Thompson, C.H.; Kemp, G.J.; Radda, G.K. |
| Erschienen in: | Acta physiologica Scandinavica |
| Veröffentlicht: | 146 (1992), 1, S. 15-19, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 0001-6772, 1365-201X |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU199210059442 |
| Quelle: | BISp |
| id |
PU199210059442 |
|---|---|
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db |
| format |
Literatur |
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2008-05-13T12:42:43Z |
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2003-12-30T14:25:17Z |
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BISp |
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Zeitschriftenartikel |
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JO00000000032 |
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JOI199200010000032 |
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Acta physiologica Scandinavica |
| hierarchy_parent_title |
Acta physiologica Scandinavica, 1992, 1 |
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PU199210059442 |
| is_hierarchy_title |
Changes in high-energy phosphates in rat skeletal muscle during acute respiratory acidosis |
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0015 |
| recordtype |
bisparticle |
| publishDate |
1992 |
| publishDate_facet |
1992 |
| language |
eng |
| title |
Changes in high-energy phosphates in rat skeletal muscle during acute respiratory acidosis |
| spellingShingle |
Changes in high-energy phosphates in rat skeletal muscle during acute respiratory acidosis ATP Azidose Kohlendioxydatmung Mitochondrienstoffwechsel Muskelstoffwechsel pH-Wert Phosphat, energiereiches Skelettmuskulatur Sportmedizin Tierversuch |
| title_sort |
changes in highenergy phosphates in rat skeletal muscle during acute respiratory acidosis |
| title_short |
Changes in high-energy phosphates in rat skeletal muscle during acute respiratory acidosis |
| title_alt |
Konzentrationsaenderungen der energiereichen Phosphate im Skelettmuskel der Ratte bei akuter respiratorischer Azidose |
| title_alt_lang |
deu |
| media_type |
Gedruckte Ressource |
| city |
Stockholm |
| abstract |
We used 31P magnetic resonance spectroscopy to study changes in phosphorus metabolite concentrations in rat skeletal muscle during respiratory acidosis (14 and 20 inspired CO2) and recovery. As intracellular pH fell (from 7.05 to 6.75 after 20 min of 20 CO2), intracellular <Pi> increased by up to 50 while phosphocreatine concentration decreased by up to 8. The sum of all intracellular phosphates remained constant. <ADP> decreased by up to 40 in accordance with the creatine kinase equilibrium but the phosphorylation potential <ATP>/(<ADP><Pi>) was preserved as a result of increased <Pi>. This adjustment may be a mechanism for maintaining mitochondrial ATP synthesis despite low pH. Eventually this increase in cellular <Pi> could lead to slow efflux of Pi from the skeletal muscle cell contributing to the hyperphosphataemia of acute respiratory acidosis. Verf.-Referat |
| abstract_lang |
eng |
| abstract_type |
abstract |
| author2 |
Thompson, C.H. Kemp, G.J. Radda, G.K. |
| author_facet |
Thompson, C.H. Kemp, G.J. Radda, G.K. |
| author2-role |
Autor Autor Autor |
| author2-authorityid |
|
| author_author_facet |
Thompson, C.H. Kemp, G.J. Radda, G.K. |
| author2-synonym |
|
| author2_hierarchy_facet |
0/Autor/ 1/Autor/Thompson, C.H./ 0/Autor/ 1/Autor/Kemp, G.J./ 0/Autor/ 1/Autor/Radda, G.K./ |
| issn |
0001-6772 1365-201X |
| spelling |
0001-6772 1365-201X APSCA 101-6 ATP Azidose Kohlendioxydatmung Mitochondrienstoffwechsel Muskelstoffwechsel pH-Wert Phosphat, energiereiches Skelettmuskulatur Sportmedizin Tierversuch acidosis animal experiment ATP carbon dioxide breathing energy-rich phosphate mitochondrial metabolism muscle metabolism pH value skeletal muscles sports medicine Azidose, metabolische Laktatazidose Azidose, respiratorische GMP Atmungskette Maus Ratte Tierexperiment Muskulatur Skelettmuskel Muskel Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf carbon dioxide inhalation adenosine triphosphate Changes in high-energy phosphates in rat skeletal muscle during acute respiratory acidosis PU199210059442 199210059442 |
| coden |
APSCA |
| zdb |
101-6 |
| location_hierarchy_facet |
0/Schweden/ |
| topic |
ATP Azidose Kohlendioxydatmung Mitochondrienstoffwechsel Muskelstoffwechsel pH-Wert Phosphat, energiereiches Skelettmuskulatur Sportmedizin Tierversuch |
| topic_facet |
ATP Azidose Kohlendioxydatmung Mitochondrienstoffwechsel Muskelstoffwechsel pH-Wert Phosphat, energiereiches Skelettmuskulatur Sportmedizin Tierversuch |
| topic_en |
acidosis animal experiment ATP carbon dioxide breathing energy-rich phosphate mitochondrial metabolism muscle metabolism pH value skeletal muscles sports medicine |
| topic_en_facet |
acidosis animal experiment ATP carbon dioxide breathing energy-rich phosphate mitochondrial metabolism muscle metabolism pH value skeletal muscles sports medicine |
| synonym |
Azidose, metabolische Laktatazidose Azidose, respiratorische GMP Atmungskette Maus Ratte Tierexperiment Muskulatur Skelettmuskel Muskel Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf |
| synonym_en |
carbon dioxide inhalation adenosine triphosphate |
| journal_facet |
Acta physiologica Scandinavica |
| container_title |
Acta physiologica Scandinavica |
| container_volume |
146 |
| container_issue |
1 |
| container_start_page |
S. 15-19 |
| has_references |
1 |
| institution |
BISp |
| journal_fac |
JO00000000032 |
| journal_year |
1992 |
| journal_issue |
1 |
| _version_ |
1810308224549650432 |
| score |
13,263324 |