Short-term effects of anabolic steroid and testosterone administration on serum lipoproteins, sex hormones and body composition
Deutscher übersetzter Titel: | Auswirkungen von kurzfristiger Einnahme von anabolen Steroiden und Testosteron auf die Serum-Lipoproteine, die Geschlechtshormone und die Koerperzusammensetzung |
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Autor: | Dolny, D.G.; Hackney, Anthony Carl; Zanten, E.L. van |
Erschienen in: | Biology of sport |
Veröffentlicht: | 9 (1992), 1, S. 25-32, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0860-021X, 2083-1862 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199207057121 |
Quelle: | BISp |
Abstract
While maintaining heavy resistance training (HRT) regimen, five experienced weightlifters aged 22.4 +/- 0.5 initiated a six week cycle of self-administered anabolic steroids (methandrostenolone, oxandrolonbe, nandrolone decanoate, testosterone cypionate). Prior to, and during the last week of AS use, body composition was quantified by hydrostatic weighing, and serum was analyzed for cortisol (C), prolactin (PRL), luteinizing hormone (LH), estradiol (E2), free (FT) and total (T) testosterone, triglycerides (TG), total (TC), high-density (HDL-C), and low-density lipoprotein (LDL-C). Body weight (+/- SE) increased (P<0.05) from 97.82 +/- 1.06 to 101.86 +/- 1.39 kg, with an increase (P<0.05) in lean body weight (83.01 +/- 1.23 vs. 87.05 +/- 1.59 kg). C was unchanged, while PRL (5.40 +/- 1.24 vs. 4.68 +/- 1.11 ng/ml), LH (8.18 +/- 2.02 vs. 7.28 +/- 3.04 mlU/ML), and E2 (38.38 +/- 14.56 vs. 19.32 +/- 1.65 pg/ml) tended to decrease. Both T (7.02 +/- 1.44 vs. 14.36 +/- 3.66 ng/ml) and FT (24.58 +/- 5.08 vs. 50.28 +/- 12.82 pg/ml) increased nearly significantly (P=0.06). TG and TC remained unchanged, however HDL-C was significantly lower (41.2 +/- 11.4 vs 24.6 +/- 9.1 mg/dl) and LDL-C was significantly higher (133 +/- 26.1 vs. 152 +/- 28.2 mg/dl) following AS. These results suggest that AS during HRT increases atherogenic blood lipoprotein profile, and causes minor alterations in hypothalamic-pituitary functions. Verf.-Referat