Morphological adaptations of human skeletal muscle to chronic hypoxia
Deutscher übersetzter Titel: | Morphologische Anpassungen der menschlichen Skelettmuskulatur an chronische Hypoxie |
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Autor: | Hoppeler, Hans H.; Kleinert, E.; Schlegel, C.; Claassen, H.; Howald, H.; Kayar, S.R.; Cerretelli, P. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 11 (1990), Suppl.1, S. S3-S9, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199005043453 |
Quelle: | BISp |
Abstract
Muscle structural changes during typical mountaineering expeditions to the Himalayas were assessed by taking muscle biopsies from 14 mountaineers before and after their sojourn at high altitude (>5000 m for over 8 weeks). M. vastus lateralis samples were analyzed morphometrically from electron micrographs. A significant reduction (-10) of muscle cross-sectional area was found on CT scans of the thigh. Morphologically this loss in muscle mass appeared as a decrease in muscle fiber size mainly due to a loss of myofibrillar proteins. A loss of muscle oxidative capacity was also evident, as indicated by a decrease in the volume muscle mitochondria (-25). In contrast, the capillary network was mostly spared from catabolism. It is therefore concluded that oxygen availability to muscle mitochondria after prolonged high-altitude exposure in humans is improved due to an unchanged capillary network, supplying a reduced muscle oxidative capacity. Verf.-Referat