Proliferation of motor end-plates induced by increased muscular activity
Deutscher übersetzter Titel: | Durch verstaerkte Muskelaktivitaet hervorgerufene Wucherung der motorischen Endplatten |
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Autor: | Appell, Hans-Joachim |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 5 (1984), 3, S. 125-129, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-2008-1025893 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU198405021519 |
Quelle: | BISp |
Abstract
The effects of muscular activity on the motor end-plates were studied. To simulate an overload training on the diaphragm, Japanese waltzer mice were subjected to hypobaric hypoxia (simulated altitude of 3000 m) for 7 and 14 days. After demonstration of the end-plates by AChE-staining, their size and total number in the sternal part of the diaphragm were measured at the light microscopic level. The end-plate regions were enlarged after 7 days and were increased in number after 14 days. These changes can probably be explained by the mechanisms of terminal and collateral sprouting. The electron-microscopic examination showed no ultrastructural peculiarities in either of the experimental groups. The muscle fibers of the trained animals showed a strong reaction of AChE; thus, it was suggested that end-plate proliferation was myogenically induced. Verf.-Referat