Differentiation of ring-substituted regioisomers of amphetamine and methamphetamine by supercritical fluid chromatography
Gespeichert in:
| Deutscher übersetzter Titel: | Differenzierung ringsubstituierter Regioisomere von Amphetamin und Methamphetamin durch superkritische Flüssigkeitschromatographie |
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| Autor: | Segawa, Hiroki; Iwata, Yuko T.; Yamamuro, Tadashi; Kuwayama, Kenji; Tsujikawa, Kenji; Kanamori, Tatsuyuki; Inoue, Hiroyuki |
| Erschienen in: | Drug testing and analysis |
| Veröffentlicht: | 9 (2017), 3/4 (Addressing the challenges in forensic drug chemistry), S. 389-398, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 1942-7603, 1942-7611 |
| DOI: | 10.1002/dta.2040 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201705003844 |
| Quelle: | BISp |
Abstract des Autors
Chromatographic differentiation of the ring-substituted regioisomers of amphetamine (AMP) and methamphetamine (MA) was performed by supercritical fluid chromatography (SFC). The behaviour of the retention against the changes of column temperature and co-solvent proportion was studied. The obtained information facilitated the optimization of the each regioisomer. As a result, 2-, 3-, and 4-ring-substituted analogues of AMP and MA with methyl, methoxy, fluoro, chloro, and bromo groups were separated, generally within 6 min. In addition, we found that the separation pattern of the examined regioisomers was classified into two, which depended on the electron donating/withdrawing effect of the substituent. Our results indicate that SFC could be used in forensic drug analysis for fast, reliable identification of structurally similar drugs of abuse.