Method validation for d,l-isomers of methamphetamine and amphetamine by GC/MS
Gespeichert in:
| Deutscher übersetzter Titel: | Die Methodenvalidierung für d,l-Isomere von Metamphetaminen und Amphetaminen mittels GC/MS |
|---|---|
| Autor: | Pootrakronchai, R.; Kaewklum, M.; Wilairat, P.; Kusamran, T.; Anukarahanonta, T. |
| Erschienen in: | Recent advances in doping analysis (15) : Proceedings of the Manfred Donike Workshop ; 25th Cologne Workshop on Dope Analysis ; 25th February to 2nd March 2007 |
| Veröffentlicht: | Köln: Sportverl. Strauß (Verlag), 2007, S. 355-358, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201001000336 |
| Quelle: | BISp |
Abstract
Amphetamine and methamphetamine are potent central nervous system stimulants. Since 2006, the differentiation between d- and l-isomers of methamphetamine is required by WADA. There are a number of drugs that are metabolized in the body to amphetamine and/or methamphetamine: amphetaminil, benzphetamine, clobenzorex, selegiline, dimethamphetamine, ethylamphetamine, famprofazone, fencamine, fenethylline, fenproporex, furfenorax, mefenorex, mesocarb and prenylamine. Thus, it is important to separate the enantiomers of amphetamine (AP) and methamphetamine (MA) excreted in urine in order to determine the source of the originally administered drugs. The enantiomeric separation of AP and MA can be achieved using the chiral agent, (S)-(-)-N-trifluoroacetyl-prolyl chloride (l-TPC), as derivatising agent. A GC/MS procedure for separating the d,l- enantiomer of MA and AP was developed and validated. Einleitung (geändert)