Acute effect of physical exercise on serum insulin-like growth factor-binding protein 2 and 3 in healthy men : role of exercise-linked growth hormone secretion
Deutscher übersetzter Titel: | Akute Auswirkung koerperlicher Belastung auf die IGF-I-bindenden Proteine 2 und 3 bei gesunden Maennern : Bedeutung der belastungsbedingten Sekretion des Wachstumshormons |
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Autor: | DiLuigi, L.; Guidetti, L.; Nordio, M.; Baldari, C.; Romanelli, F. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 22 (2001), 2, S. 103-110, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-2001-11365 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199912501135 |
Quelle: | BISp |
Abstract des Autors
The purpose of this study was to delineate the role of GH on serum IGF-I, IGFBP-2 and -3 responses to exercise. Hormones were evaluated in six trained male subjects before (-30, -15, 0), during (+15) and after (+30, +45, +60, +90 min) a thirty-minutes treadmill exercise (60% VO2max), both after a single administration of a somatostatin analog (i.e., octreotide, 0.1 mg sc) and after saline. The same evaluations were performed without exercise with similar treatments. The results showed that: 1) octreotide significantly inhibited the GH response to exercise, 2) exercise increased IGFBP-3 concentration (+37.4% at +90, p<0.05), whereas no modification of IGFBP-2 and of IGF-I/IGFBP-2 and IGFBP-3/IGFBP-2 ratios were observed, 3) octreotide amplified the IGFBP-3 increase after exercise (p<0.01 vs. exercise, from +30 to +60, or octreotide alone) and, without exercise, slightly increased IGFBP-3 (+15% at +75, p<0.05) and decreased IGF-I (-14.8% at +75, p<0.01). We concluded that GH has a reduced role, as a stimulating factor, in the serum acute IGFBP-3 increase after exercise and that octreotide is probably able to directly amplify this response. Unfortunately, we can only speculate on the physiological pathways involved. Verf.-Referat