Plasma and urinary markers of oral testosterone misuse by healthy men in presence of masking epitestosterone administration
Deutscher übersetzter Titel: | Markersubstanzen des oralen Testosteronmissbrauchs in Plasma und Urin von gesunden Maennern bei gleichzeitiger Einnahme von maskierendem Epitestosteron |
---|---|
Autor: | Dehennin, L.; Peres, G. |
Erschienen in: | International journal of sports medicine |
Veröffentlicht: | 17 (1996), 5, S. 315-319, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Gedruckte Ressource Elektronische Ressource (online) |
Sprache: | Englisch |
ISSN: | 0172-4622, 1439-3964 |
DOI: | 10.1055/s-2007-972853 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU199608109641 |
Quelle: | BISp |
Abstract des Autors
There is a potential need for the official criterion of testosterone abuse in sport (the urinary concentration ratio of testosterone glucuronide/epitestosterone glucuronide, TG/EG>6) to be backed-up by some complementary markers, more particularly in cases of physiologically high TG/EG and when there is suspicion of joint administration of testosterone and epitestosterone. Testosterone, epitestosterone, their glucuro- and sulfoconjugates, 5-androstene-3beta, 17alpha-diol glucuronide and 17-hydroxyprogesterone have been analysed by isotope dilution-gas chromatography-mass spectrometry in plasma and urine of seven subjects supplemented with a single oral dose of undecanoates of testosterone and epitestosterone (respectively 40 mg and 1.5 mg). Adequate plasma criteria for testosterone abuse were the ratios of testosterone glucuronide/17-hydroxyprogesterone and testosterone glucuronide/testosterone which increased significantly above basal values for up to 10 h. The same trend was observed for the ratio of urinary glucuronides of testosterone/5-androstene-3beta, 17alpha-diol, while TG/EG was not affected by simultaneous administration of epitestosterone. One subject with low basal TG/EG failed to respond to testosterone administration by any significant increase of analysed parameters. Verf.-Referat