Abstract des Autors

The presented investigation deals with the question whether changes in the steroid profile after application of anabolic steroids and discontinuing the application are reversible. Urine samples of volunteers and routine dope controls were analysed by gaschromatography/mass spectrometry. Results: 1. The application of anabolic steroids in high doses leads to a highly significant decrease of the concentration and excretion of the endogenous steroids in urine, which is caused by the suppression of the endogenous steroid production through the hormonal regulation mechanism of negative feedback. 2. Another, not yet described effect of the application of anabolic steroids is the change of the endogenous steroid profile. This shows up in the concentration ratios of isomere steroids like cis-androsterone to etiocholanolone and may be interpreted as a change of activity of microsomal enzymes in the hepatic steroid metabolism. 3. High doses of anabolic steroids and longterm use lead to a very long duration of the above mentioned effects. The decrease in concentration and excretion of anabolic steroids can be observed even if the exogenous anabolic steroids can no longer be detected in urine. Verf.-Referat