Abstract

While maintaining heavy resistance training (HRT) regimen, five experienced weightlifters aged 22.4 +/- 0.5 initiated a six week cycle of self-administered anabolic steroids (methandrostenolone, oxandrolonbe, nandrolone decanoate, testosterone cypionate). Prior to, and during the last week of AS use, body composition was quantified by hydrostatic weighing, and serum was analyzed for cortisol (C), prolactin (PRL), luteinizing hormone (LH), estradiol (E2), free (FT) and total (T) testosterone, triglycerides (TG), total (TC), high-density (HDL-C), and low-density lipoprotein (LDL-C). Body weight (+/- SE) increased (P<0.05) from 97.82 +/- 1.06 to 101.86 +/- 1.39 kg, with an increase (P<0.05) in lean body weight (83.01 +/- 1.23 vs. 87.05 +/- 1.59 kg). C was unchanged, while PRL (5.40 +/- 1.24 vs. 4.68 +/- 1.11 ng/ml), LH (8.18 +/- 2.02 vs. 7.28 +/- 3.04 mlU/ML), and E2 (38.38 +/- 14.56 vs. 19.32 +/- 1.65 pg/ml) tended to decrease. Both T (7.02 +/- 1.44 vs. 14.36 +/- 3.66 ng/ml) and FT (24.58 +/- 5.08 vs. 50.28 +/- 12.82 pg/ml) increased nearly significantly (P=0.06). TG and TC remained unchanged, however HDL-C was significantly lower (41.2 +/- 11.4 vs 24.6 +/- 9.1 mg/dl) and LDL-C was significantly higher (133 +/- 26.1 vs. 152 +/- 28.2 mg/dl) following AS. These results suggest that AS during HRT increases atherogenic blood lipoprotein profile, and causes minor alterations in hypothalamic-pituitary functions. Verf.-Referat