Abstract

Exercise-induced lipolysis and hormones possibly involved in the regulation of lipid metabolism in association with exercise (plasma catecholamines, ACTH, HGH, TSH, insulin) were studied in 11 WHO stage 1 to 2 hypertensive men (mean age 37 years). All patients were again studied under identical conditions after a 4-week treatment with the beta-1-beta-2-receptor antagonist pindolol (15 mg daily) and with the beta-1-receptor blocker acebutolol (500 mg daily). Plasma glycerol levels increased progressively during exercise reflecting increased exercise-induced lipolysis. The concomitant significant rise of noradrenalin, adrenaline, ACTH, and HGH and the parallel fall in plasma insulin suggest that all these hormones are involved in the adjustment of exercise-induced lipolysis. However, the impaired catecholamine-induced lipolysis under beta-receptor blockade was not accompanied by significant compensatory increases of ACTH; HGH, or TSH or a fall in insulin during exercise. Both beta-receptor antagonists resulted in a similar 27 inhibition of lipolysis confirming that the catecholamine-induced increase of lipolysis is mainly mediated via beta-l-adrenoceptors. Verf.-Referat