Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment

Author: Noronha Osório, Daniel; Viana-Soares, Ricardo; Marto, João Pedro; Mendonça, Marcelo D.; Silva, Hugo P.; Quaresma, Cláudia; Viana-Baptista, Miguel; Gamboa, Hugo; Vieira, Helena L. A.
Language: English
Published: 2019
Source: PubMed Central (PMC)
Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734354/
https://doi.org/10.1186/s12872-019-1181-5
Identification number: ftpubmed:oai:pubmedcentral.nih.gov:6734354
id ftpubmed:oai:pubmedcentral.nih.gov:6734354
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url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734354/
https://doi.org/10.1186/s12872-019-1181-5
url-type pmc
info
publishDate 2019
publishDate_facet 2019
baseCollectionName PubMed Central (PMC)
baseCountry us
title Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
spellingShingle Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
title_short Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
title_sort Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
spelling Autonomic nervous system response to remote ischemic conditioning: heart rate variability assessment
author2 Noronha Osório, Daniel
Viana-Soares, Ricardo
Marto, João Pedro
Mendonça, Marcelo D.
Silva, Hugo P.
Quaresma, Cláudia
Viana-Baptista, Miguel
Gamboa, Hugo
Vieira, Helena L. A.
author_facet Noronha Osório, Daniel
Viana-Soares, Ricardo
Marto, João Pedro
Mendonça, Marcelo D.
Silva, Hugo P.
Quaresma, Cláudia
Viana-Baptista, Miguel
Gamboa, Hugo
Vieira, Helena L. A.
author2-role Autor
Autor
Autor
Autor
Autor
Autor
Autor
Autor
Autor
abstract BACKGROUND: Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully understood, and it is hypothesized they are mediated either by humoral factors, immune cells and/or the autonomic nervous system. Herein, heart rate variability (HRV) was used to evaluate the electrophysiological processes occurring in the heart during RIC and, in turn to assess the role of autonomic nervous system. METHODS: Healthy subjects were submitted to RIC protocol and electrocardiography (ECG) was used to evaluate HRV, by assessing the variability of time intervals between two consecutive heart beats. This is a pilot study based on the analysis of 18 ECG from healthy subjects submitted to RIC. HRV was characterized in three domains (time, frequency and non-linear features) that can be correlated with the autonomic nervous system function. RESULTS: RIC procedure increased significantly the non-linear parameter SD2, which is associated with long term HRV. This effect was observed in all subjects and in the senior (> 60 years-old) subset analysis. SD2 increase suggests an activation of both parasympathetic and sympathetic nervous system, namely via fast vagal response (parasympathetic) and the slow sympathetic response to the baroreceptors stimulation. CONCLUSIONS: RIC procedure modulates both parasympathetic and sympathetic autonomic nervous system. Furthermore, this modulation is more pronounced in the senior subset of subjects. Therefore, the autonomic nervous system regulation could be one of the mechanisms for RIC therapeutic effectiveness. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12872-019-1181-5) contains supplementary material, which is available to authorized users.
abstract_type general
abstract_lang eng
language eng
publisher BioMed Central
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score 12,731232