Efficacy of a Chinese Herbal Medicine Compound Zhangpi Ointment against Hydroxyurea-Induced Leg Ulcers: A Prospective, Randomized, Open-Label, Controlled Clinical Trial
| Autor: | Pang, Yu-yang; Li, Yan; Kui, Gang; Tang, Yong; Liao, Ming-juan; Wang, Yong-ling; Cao, Zhen-dong; Zhu, Qi |
|---|---|
| Sprache: | Englisch |
| Veröffentlicht: |
2018 |
| Quelle: | PubMed Central (PMC) |
| Online Zugang: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311290/ http://www.ncbi.nlm.nih.gov/pubmed/30643539 http://dx.doi.org/10.1155/2018/9329465 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311290/ https://doi.org/10.1155/2018/9329465 |
| Erfassungsnummer: | ftpubmed:oai:pubmedcentral.nih.gov:6311290 |
| id |
ftpubmed:oai:pubmedcentral.nih.gov:6311290 |
|---|---|
| bisp-collection |
base |
| recordtype |
bispbase |
| url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311290/ http://www.ncbi.nlm.nih.gov/pubmed/30643539 http://dx.doi.org/10.1155/2018/9329465 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311290/ https://doi.org/10.1155/2018/9329465 |
| url-type |
primary primary primary pmc info |
| publishDate |
2018 |
| publishDate_facet |
2018 |
| baseCollectionName |
PubMed Central (PMC) |
| baseCountry |
us |
| title |
Efficacy of a Chinese Herbal Medicine Compound Zhangpi Ointment against Hydroxyurea-Induced Leg Ulcers: A Prospective, Randomized, Open-Label, Controlled Clinical Trial |
| spellingShingle |
Efficacy of a Chinese Herbal Medicine Compound Zhangpi Ointment against Hydroxyurea-Induced Leg Ulcers: A Prospective, Randomized, Open-Label, Controlled Clinical Trial |
| title_short |
Efficacy of a Chinese Herbal Medicine Compound Zhangpi Ointment against Hydroxyurea-Induced Leg Ulcers: A Prospective, Randomized, Open-Label, Controlled Clinical Trial |
| title_sort |
Efficacy of a Chinese Herbal Medicine Compound Zhangpi Ointment against Hydroxyurea-Induced Leg Ulcers: A Prospective, Randomized, Open-Label, Controlled Clinical Trial |
| spelling |
Efficacy of a Chinese Herbal Medicine Compound Zhangpi Ointment against Hydroxyurea-Induced Leg Ulcers: A Prospective, Randomized, Open-Label, Controlled Clinical Trial |
| author2 |
Pang, Yu-yang Li, Yan Kui, Gang Tang, Yong Liao, Ming-juan Wang, Yong-ling Cao, Zhen-dong Zhu, Qi |
| author_facet |
Pang, Yu-yang Li, Yan Kui, Gang Tang, Yong Liao, Ming-juan Wang, Yong-ling Cao, Zhen-dong Zhu, Qi |
| author2-role |
Autor Autor Autor Autor Autor Autor Autor Autor |
| abstract |
Objective. The randomized controlled trial was to evaluate the efficacy of topical Chinese herbal Zhangpi Ointment for hydroxyurea-induced leg ulcers in patients with myeloproliferative neoplasms. Patients and Methods. This single-center, prospective, randomized, open-label, controlled clinical trial conducted at Shanghai Ninth People's Hospital enrolled 54 patients with hydroxyurea-induced leg ulcers. Patients were randomly assigned to the control group (n = 27) treated with chlorhexidine dressing or the intervention group (n = 27) treated with the Zhangpi Ointment. Finally, 26 patients in the control group and 23 patients in the intervention group completed 8 weeks of observation. Results. The rate of complete healing was 100% for the intervention group, which was significantly higher than that of the control group (96.15%) (P<0.05). Furthermore, the intervention group achieved a significantly higher rate of wound healing (95.56%) than the control group (69.02%) at week 4 (P<0.01). The intervention group took 34 ± 5 days to achieve complete healing while the control group took 41 ± 7 days (P < 0.01). Moreover, grade 3/4 side effects were observed in neither group. Conclusion. The Zhangpi Ointment is effective in promoting the healing of hydroxyurea-induced leg ulcers in patients with myeloproliferative neoplasms, providing a therapeutic option for a condition that is recalcitrant to conventional therapy. |
| abstract_type |
general |
| abstract_lang |
eng |
| language |
eng |
| publisher |
Hindawi |
| _version_ |
1793496212915093504 |
| score |
13,546046 |