Endothelial ischemia-reperfusion injury in humans: association with age and habitual exercise
Autor: | DeVan, Allison E.; Umpierre, Daniel; Harrison, Michelle L.; Lin, Hsin-Fu; Tarumi, Takashi; Renzi, Christopher P.; Dhindsa, Mandeep; Hunter, Stacy D.; Tanaka, Hirofumi |
---|---|
Sprache: | Englisch |
Veröffentlicht: |
2011 |
Quelle: | PubMed Central (PMC) |
Online Zugang: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064302 http://www.ncbi.nlm.nih.gov/pubmed/21239631 http://dx.doi.org/10.1152/ajpheart.00845.2010 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064302 https://doi.org/10.1152/ajpheart.00845.2010 |
Erfassungsnummer: | ftpubmed:oai:pubmedcentral.nih.gov:3064302 |
Zusammenfassung
Advancing age is a major risk factor for coronary artery disease. Endothelial dysfunction accompanied by increased oxidative stress and inflammation with aging may predispose older arteries to greater ischemia-reperfusion (I/R) injury. Because coronary artery ischemia cannot be induced safely, the effects of age and habitual endurance exercise on endothelial I/R injury have not been determined in humans. Using the brachial artery as a surrogate model of the coronary arteries, endothelial function, assessed by brachial artery flow-mediated dilation (FMD), was measured before and after 20 min of continuous forearm occlusion in young sedentary (n = 10, 24 ± 2 yr) and middle-aged (n = 9, 48 ± 2 yr) sedentary adults to gain insight into the effects of primary aging on endothelial I/R injury. Young (n = 9, 25 ± 1 yr) and middle-aged endurance-trained (n = 9, 50 ± 2 yr) adults were also studied to determine whether habitual exercise provides protection from I/R injury. Fifteen minutes after ischemic injury, FMD decreased significantly by 37% in young sedentary, 35% in young endurance-trained, 68% in middle-aged sedentary, and 50% in middle-aged endurance-trained subjects. FMD returned to baseline levels within 30 min in young sedentary and endurance-trained subjects but remained depressed in middle-aged sedentary and endurance-trained subjects. Circulating markers of antioxidant capacity and inflammation were not related to FMD. In conclusion, advancing age is associated with a greater magnitude and delayed recovery from endothelial I/R injury in humans. Habitual endurance exercise may provide partial protection to the endothelium against this form of I/R injury with advancing age.