Zusammenfassung

Olfat Abdelmoniem Ibrahem Amin,1 Mohamed Abdel-moniem Ibrahem,2 Dina Abdelhameed Elsadek Salem1 1Anesthesia and Surgical Intensive Care Department, Faculty of Medicine, Zagazig University, Alsharkia, Egypt; 2Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University, Alsharkia, EgyptCorrespondence: Olfat Abdelmoniem Ibrahem AminAnesthesia and Surgical Intensive Care Department,Faculty of Medicine, Zagazig University, Alsharkia, EgyptTel +201004528999Email olfath99@yahoo.comBackground and Purpose: Adding adjuvants to intrathecal hyperbaric bupivacaine provides long analgesic duration with less adverse effects. The aim of this study was to compare intrathecal nalbuphine versus midazolam in patients undergoing cesarean section.Clinical Trial ID: NCT03918187.Patients and Methods: This was a prospective randomized controlled study conducted on 90 females undergoing cesarean section under spinal anesthesia who were randomly allocated to three equal groups of 30 patients each: group C received hyperbaric bupivacaine 12.5 mg plus 0.5 mL saline, group N received hyperbaric bupivacaine 12.5 mg plus 1 mg nalbuphine, group M received hyperbaric bupivacaine 12.5 mg plus 2.5 mg midazolam. The onset and duration of sensory and motor block, effective analgesic time, analgesic requirements, adverse effects, sedation, and Apgar scores were recorded.Results: There was significant rapid onset of sensory and motor block (1.95±.44 and 3.50± 0.43 min) with slower regression of sensory block and time to bromage I (211.6± 13.2 and 219.8± 20.2 min) in group N compared to groups M, C (p < 0.001), with statistically significant rapid onset and long duration of both blocks in group M compared to C (p< 0.001). The effective analgesic time was significantly prolonged in group N (263.7± 16.3) compared to groups M and C (224.2 ± 18.6, 185.5± 17.45), respectively, (p< 0.001) and prolonged in group M compared to C (p< 0.001), with increase in analgesic requirement in group C compared to groups N and M (p< 0.001) ...