Ecdysteroids: A novel class of anabolic agents?
Autor: | MK Parr; F Botrè; A Naß; J Hengevoss; P Diel |
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Sprache: | Englisch |
Veröffentlicht: |
2015 |
Quelle: | Directory of Open Access Journals: DOAJ Articles |
Online Zugang: |
http://www.termedia.pl/Ecdysteroids-A-novel-class-of-anabolic-agents-,78,25160,1,1.html https://doaj.org/toc/0860-021X https://doaj.org/toc/2083-1862 0860-021X 2083-1862 doi:10.5604/20831862.1144420 https://doaj.org/article/503d80566b1a4f42b8cc2b5a18d6b975 https://doi.org/10.5604/20831862.1144420 https://doaj.org/article/503d80566b1a4f42b8cc2b5a18d6b975 |
Erfassungsnummer: | ftdoajarticles:oai:doaj.org/article:503d80566b1a4f42b8cc2b5a18d6b975 |
Zusammenfassung
Increasing numbers of dietary supplements with ecdysteroids are marketed as “natural anabolic agents”. Results of recent studies suggested that their anabolic effect is mediated by estrogen receptor (ER) binding. Within this study the anabolic potency of ecdysterone was compared to well characterized anabolic substances. Effects on the fiber sizes of the soleus muscle in rats as well the diameter of C2C12 derived myotubes were used as biological readouts. Ecdysterone exhibited a strong hypertrophic effect on the fiber size of rat soleus muscle that was found even stronger compared to the test compounds metandienone (dianabol), estradienedione (trenbolox), and SARM S 1, all administered in the same dose (5 mg/kg body weight, for 21 days). In C2C12 myotubes ecdysterone (1 μM) induced a significant increase of the diameter comparable to dihydrotestosterone (1 μM) and IGF 1 (1.3 nM). Molecular docking experiments supported the ERβ mediated action of ecdysterone. To clarify its status in sports, ecdysterone should be considered to be included in the class “S1.2 Other Anabolic Agents” of the list of prohibited substances of the World Anti-Doping Agency.