Zusammenfassung

PURPOSE The purpose of this study was to investigate the association of relative hand-grip strength (HGS) with incident metabolic syndrome (MetS) in Korean adults using a community-based cohort study. METHODS Total of 17,271 subjects (4,083 men and 13,188 women) aged 40-64, who participated in the Korean Genome and Epidemiology Study (KoGES) were included. HGS was tested using a handgrip dynamometer and divided by body mass index (BMI). The diagnosis of MetS was evaluated according to the definition of the National Cholesterol Education Program Adult Treatment Panel III. Cox’s proportional hazard regression analysis was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of MetS incidence according to HGS levels. RESULTS During the mean follow-up period of 5 years, the incidence of MetS was 435 (10.7%) and 1,260 (8.9%) subjects in men and women, respectively. Compared to the Low HGS (reference, HR=1), the reduced MetS incidence of high HGS (HR=0.425, 95%CI=0.326-0.556, p<.001) in men and mid HGS (HR=0.859, 95%CI=0.752-0.980, p<.05) and high HGS (HR=0.564, 95%CI=0.564-0.756, p<.001) in women remained significant even after the adjustment for age, income, education, marriage, alcohol consumption, smoking and exercise. CONCLUSIONS Maintaining a high level of HGS may be important strategies for MetS prevention among adults.