Correlation between obesity, adipokines and the immune system
Autor: | Marcos Regini Silveira; Anelena Bueno Frollini; Rozângela Verlengia; Cláudia Regina Cavaglieri |
---|---|
Sprache: | Englisch; Portugiesisch |
Veröffentlicht: |
2009 |
Quelle: | Directory of Open Access Journals: DOAJ Articles |
Online Zugang: |
http://www.periodicos.ufsc.br/index.php/rbcdh/article/view/6254/10916 https://doaj.org/toc/1415-8426 https://doaj.org/toc/1980-0037 1415-8426 1980-0037 https://doaj.org/article/0cd66cbb3c9b4b2fa69b4c0237f703c0 https://doaj.org/article/0cd66cbb3c9b4b2fa69b4c0237f703c0 |
Erfassungsnummer: | ftdoajarticles:oai:doaj.org/article:0cd66cbb3c9b4b2fa69b4c0237f703c0 |
Zusammenfassung
Obesity is a worldwide health problem and the increase in its incidence, risks and consequences are a matter of growing concern. Obesity is characterized by the accumulation of fat in the body. Many studies are currently investigating obesity and associated comorbidities in an attempt to clarify the mechanisms involved. Fat tissue is a dynamic organ that secretes several factors, including adipokines. Adipokines are bioactive peptides secreted by fat cells, which are important for energy regulation and inflammatory and immune responses. Leptin, adiponectin and resistin are the most studied adipokines. The aim of this review was to gather information about these adipokines (leptin, adiponectin and resistin) and their relationship with the immune response in obese individuals, as well as the susceptibility of these patients to infections. The results of the literature review permit some observations. The circulating levels of these adipokines are directly involved in the degree of obesity of the patient. High or low circulating concentrations of these adipokines may have beneficial or negative effects on immune competence, with obese patients being more susceptible to infection and inflammation than eutrophic individuals.Key words: Obesity; Adipokines; Leptin; Adiponectin; Resistin; Immune system.