Structural trace of adaptation in motive nuclei of spinal cord of rats in hypokinesia and after physical loading in the recovery period

Autor: S. L. Popel; B. M. Mitckan; S. Z. Krasnopolsky; I. V. Melnik
Sprache: Englisch; Russisch; Ukrainisch
Veröffentlicht: 2015
Quelle: Directory of Open Access Journals: DOAJ Articles
Online Zugang: http://medicine.dp.ua/index.php/med/article/view/237
https://doaj.org/toc/2310-4155
https://doaj.org/toc/2312-7295
2310-4155
2312-7295
doi:10.15421/021502
https://doaj.org/article/08be0b20b2c64a98a591f023e03a3a70
https://doi.org/10.15421/021502
https://doaj.org/article/08be0b20b2c64a98a591f023e03a3a70
Erfassungsnummer: ftdoajarticles:oai:doaj.org/article:08be0b20b2c64a98a591f023e03a3a70

Zusammenfassung

The purpose of this paper is to study the morphological changes of neurocytes in spinal cord of rats in hypokinesia and subsequent physical loading. Studies were performed on 55 laboratory rats of Wistar line. Materials of the research were the anterior horns of the gray matter of L5-S2 spinal segments. Preparations stained by Nissl and Viktorov were examined histologically. Hypokinesia was modeled following on the author’s technique. It was established that during prolonged hypokinesia in neurocytes of spinal cord of rats morphological changes in cell size and shape of the motor nuclei of all segments under study have been recorded. The number of hypochromic, hyperchromic destructively unchanged and hyperchromic destructively altered neurocytes increase; shadow cells appears, as well as cases of satellitosis and neuronophagia. Decrease in of albumen synthetical neurocyte function has been recorded. Physical loading of the average aerobic capacity leads to normalization of structural and functional state of neurocytes and enhances the reparative processes, as evidenced by a number of positive changes in morphometric parameters: increase in the number of normochromic neurocytes and decreasing the number of hyper- and hypochromic neurocytes with destructive signs, absence of pyknotic forms. Morphological parameters of neurocytes and their nuclei after physical loading of average aerobic capacity do not differ from those in the control group of intact animals. In neurocytes of this group of rats RNA concentration increases by 12.6% compared to animals after prolonged hypokinesia. Neurocytes of spinal cord of rats after prolonged hypokinesia develop significant morphological changes which are characterized by emergence of a significant number of hyperchromic neurocytes with signs of destructive changes and shadow cells, as well as and hypochromic neurocytes with signs of destructive changes, reduction in size and change of shape of perikaryons of neurocytes and their nuclei. Morphological changes of neurocytes after ...