Tau Positron-Emission Tomography in former National Football League players
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| Deutscher übersetzter Titel: | Tau-Positron-Emissions-Tomographie bei ehemaligen Spielern der National Football League (NFL) |
|---|---|
| Autor: | Stern, Robert A.; Adler, Charles H.; Chen, Kewei; Navitsky, Michael; Luo, Ji; Dodick, David W.; Alosco, Michael L.; Tripodis, Yorghos; Goradia, Dhruman D.; Martin, Brett; Mastroeni, Diego; Fritts, Nathan G.; Jarnagin, Johnny; Devous, Michael D.; Mintun, Mark A.; Pontecorvo, Michael J.; Shenton, Martha E.; Reiman, Eric M. |
| Erschienen in: | The New England journal of medicine |
| Veröffentlicht: | 2019, vorab online, vorab online, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Elektronische Ressource (online) |
| Sprache: | Englisch |
| ISSN: | 0028-4793, 1533-4406 |
| DOI: | 10.1056/NEJMoa1900757 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201904002915 |
| Quelle: | BISp |
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Literatur |
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2019-04-15T14:24:37Z |
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2019-04-15T14:05:03Z |
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JO00000001063 |
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JOI20198bc50001063 |
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The New England journal of medicine |
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The New England journal of medicine, 2019, vorab online |
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PU201904002915 |
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Tau Positron-Emission Tomography in former National Football League players |
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bisparticle |
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2019 |
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2019 |
| language |
eng |
| title |
Tau Positron-Emission Tomography in former National Football League players |
| spellingShingle |
Tau Positron-Emission Tomography in former National Football League players American Football Degeneration Demenz Diagnostische Verfahren Enzephalopathie Enzephalopathie, chronisch-traumatische Gehirnerschütterung Gehirnerschütterung Hochleistungssport Neurologie Neuropathologie Neurophysiologie Neuropsychologie Pathologie Profisport Protein Rehabilitation, posttraumatische Schädelhirnverletzung Schädelverletzung Sportmedizin Sportpathologie Symptomatik Therapeutische Verfahren Tomographie Untersuchung, empirische Zustand, posttraumatischer |
| title_sort |
tau positronemission tomography in former national football league players |
| title_short |
Tau Positron-Emission Tomography in former National Football League players |
| title_alt |
Tau-Positron-Emissions-Tomographie bei ehemaligen Spielern der National Football League (NFL) |
| title_alt_lang |
deu |
| media_type |
Elektronische Ressource (online) |
| city |
Waltham (Mass.) |
| abstract |
Background
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that has been associated with a history of repetitive head impacts. The neuropathological diagnosis is based on a specific pattern of tau deposition with minimal amyloid-beta deposition that differs from other disorders, including Alzheimer’s disease. The feasibility of detecting tau and amyloid deposition in the brains of living persons at risk for CTE has not been well studied.
Methods
We used flortaucipir positron-emission tomography (PET) and florbetapir PET to measure deposition of tau and amyloid-beta, respectively, in the brains of former National Football League (NFL) players with cognitive and neuropsychiatric symptoms and in asymptomatic men with no history of traumatic brain injury. Automated image-analysis algorithms were used to compare the regional tau standardized uptake value ratio (SUVR, the ratio of radioactivity in a cerebral region to that in the cerebellum as a reference) between the two groups and to explore the associations of SUVR with symptom severity and with years of football play in the former-player group.
Results
A total of 26 former players and 31 controls were included in the analysis. The mean flortaucipir SUVR was higher among former players than among controls in three regions of the brain: bilateral superior frontal (1.09 vs. 0.98; adjusted mean difference, 0.13; 95% confidence interval [CI], 0.06 to 0.20; P<0.001), bilateral medial temporal (1.23 vs. 1.12; adjusted mean difference, 0.13; 95% CI, 0.05 to 0.21; P<0.001), and left parietal (1.12 vs. 1.01; adjusted mean difference, 0.12; 95% CI, 0.05 to 0.20; P=0.002). In exploratory analyses, the correlation coefficients in these three regions between the SUVRs and years of play were 0.58 (95% CI, 0.25 to 0.79), 0.45 (95% CI, 0.07 to 0.71), and 0.50 (95% CI, 0.14 to 0.74), respectively. There was no association between tau deposition and scores on cognitive and neuropsychiatric tests. Only one former player had levels of amyloid-beta deposition similar to those in persons with Alzheimer’s disease.
Conclusions
A group of living former NFL players with cognitive and neuropsychiatric symptoms had higher tau levels measured by PET than controls in brain regions that are affected by CTE and did not have elevated amyloid-beta levels. Further studies are needed to determine whether elevated CTE-associated tau can be detected in individual persons. (Funded by Avid Radiopharmaceuticals and others.) |
| abstract_lang |
eng |
| abstract_type |
abstract |
| author2 |
Stern, Robert A. Adler, Charles H. Chen, Kewei Navitsky, Michael Luo, Ji Dodick, David W. Alosco, Michael L. Tripodis, Yorghos Goradia, Dhruman D. Martin, Brett Mastroeni, Diego Fritts, Nathan G. Jarnagin, Johnny Devous, Michael D. Mintun, Mark A. Pontecorvo, Michael J. Shenton, Martha E. Reiman, Eric M. |
| author_facet |
Stern, Robert A. Adler, Charles H. Chen, Kewei Navitsky, Michael Luo, Ji Dodick, David W. Alosco, Michael L. Tripodis, Yorghos Goradia, Dhruman D. Martin, Brett Mastroeni, Diego Fritts, Nathan G. Jarnagin, Johnny Devous, Michael D. Mintun, Mark A. Pontecorvo, Michael J. Shenton, Martha E. Reiman, Eric M. |
| author2-role |
Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor |
| author2-authorityid |
P342271 |
| author_author_facet |
Stern, Robert A. Adler, Charles H. Chen, Kewei Navitsky, Michael Luo, Ji Dodick, David W. Alosco, Michael L. Tripodis, Yorghos Goradia, Dhruman D. Martin, Brett Mastroeni, Diego Fritts, Nathan G. Jarnagin, Johnny Devous, Michael D. Mintun, Mark A. Pontecorvo, Michael J. Shenton, Martha E. Reiman, Eric M. |
| author2-synonym |
|
| author2_hierarchy_facet |
0/Autor/ 1/Autor/Stern, Robert A./ 0/Autor/ 1/Autor/Adler, Charles H./ 0/Autor/ 1/Autor/Chen, Kewei/ 0/Autor/ 1/Autor/Navitsky, Michael/ 0/Autor/ 1/Autor/Luo, Ji/ 0/Autor/ 1/Autor/Dodick, David W./ 0/Autor/ 1/Autor/Alosco, Michael L./ 0/Autor/ 1/Autor/Tripodis, Yorghos/ 0/Autor/ 1/Autor/Goradia, Dhruman D./ 0/Autor/ 1/Autor/Martin, Brett/ 0/Autor/ 1/Autor/Mastroeni, Diego/ 0/Autor/ 1/Autor/Fritts, Nathan G./ 0/Autor/ 1/Autor/Jarnagin, Johnny/ 0/Autor/ 1/Autor/Devous, Michael D./ 0/Autor/ 1/Autor/Mintun, Mark A./ 0/Autor/ 1/Autor/Pontecorvo, Michael J./ 0/Autor/ 1/Autor/Shenton, Martha E./ 0/Autor/ 1/Autor/Reiman, Eric M./ |
| doi |
10.1056/NEJMoa1900757 |
| spelling |
10.1056/NEJMoa1900757 0028-4793 1533-4406 NEJMA ; NEJMAG 207154-x American Football Degeneration Demenz Diagnostische Verfahren Enzephalopathie Enzephalopathie, chronisch-traumatische Gehirnerschütterung Gehirnerschütterung Hochleistungssport Neurologie Neuropathologie Neurophysiologie Neuropsychologie Pathologie Profisport Protein Rehabilitation, posttraumatische Schädelhirnverletzung Schädelverletzung Sportmedizin Sportpathologie Symptomatik Therapeutische Verfahren Tomographie Untersuchung, empirische Zustand, posttraumatischer American Football chronic traumatic encephalopathy concussion of the brain coomotio cerebri craniocerebral injury degeneration dementia diagnostic procedures empirical investigation encephalopathy neurology neuropathology neurophysiology neuropsychology pathology post-traumatic rehabilitation posttraumatic state professional sport protein skull injury sport pathology sports medicine symptoms and signs therapeutic methods tomography top-level sport Hirnkontusion Symptom Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf Diagnose Diagnosemethode Diagnostik Untersuchungsdiagnostik Behandlung Behandlungsmethode Heilverfahren Therapie Physiologie Boxerenzephalopathie CTE Dementia pugilistica Chronisch-traumatische Enzephalopathie Hirngeschädigter Hirnschaden Meningoenzephalitis Pathologie Eiweiss Plasmaprotein Empirie Empirismus Untersuchung, experimentelle Untersuchung Footballspieler Touchdown Fullback Halfback Quarterback Hochleistungssportler Spitzensport Wettbewerbssport Wettkampfsport Hochleistungssportlerin Hochleistungstraining Höchstleistungstraining Spitzensportler Berufssport Berufssportler Professional Professionalismus Profitum brain concussion cerebral commotion commotio cerebri boxer encephalopathy dementia pugilistica cerebropathy brain disease cranial injury injury of the skull injury of the cranium empirical study high-performance sport Tau Positron-Emission Tomography in former National Football League players PU201904002915 201904002915 |
| url |
https://www.nejm.org/doi/pdf/10.1056/NEJMoa1900757 https://dx.doi.org/10.1056/NEJMoa1900757 |
| url-type |
fulltext fulltext |
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0 0 |
| issn |
0028-4793 1533-4406 |
| coden |
NEJMA ; NEJMAG |
| zdb |
207154-x |
| location_hierarchy_facet |
0/USA/ 1/USA/Massachusetts/ |
| topic |
American Football Degeneration Demenz Diagnostische Verfahren Enzephalopathie Enzephalopathie, chronisch-traumatische Gehirnerschütterung Gehirnerschütterung Hochleistungssport Neurologie Neuropathologie Neurophysiologie Neuropsychologie Pathologie Profisport Protein Rehabilitation, posttraumatische Schädelhirnverletzung Schädelverletzung Sportmedizin Sportpathologie Symptomatik Therapeutische Verfahren Tomographie Untersuchung, empirische Zustand, posttraumatischer |
| topic_facet |
American Football Degeneration Demenz Diagnostische Verfahren Enzephalopathie Enzephalopathie, chronisch-traumatische Gehirnerschütterung Gehirnerschütterung Hochleistungssport Neurologie Neuropathologie Neurophysiologie Neuropsychologie Pathologie Profisport Protein Rehabilitation, posttraumatische Schädelhirnverletzung Schädelverletzung Sportmedizin Sportpathologie Symptomatik Therapeutische Verfahren Tomographie Untersuchung, empirische Zustand, posttraumatischer |
| topic_en |
American Football chronic traumatic encephalopathy concussion of the brain coomotio cerebri craniocerebral injury degeneration dementia diagnostic procedures empirical investigation encephalopathy neurology neuropathology neurophysiology neuropsychology pathology post-traumatic rehabilitation posttraumatic state professional sport protein skull injury sport pathology sports medicine symptoms and signs therapeutic methods tomography top-level sport |
| topic_en_facet |
American Football chronic traumatic encephalopathy concussion of the brain coomotio cerebri craniocerebral injury degeneration dementia diagnostic procedures empirical investigation encephalopathy neurology neuropathology neurophysiology neuropsychology pathology post-traumatic rehabilitation posttraumatic state professional sport protein skull injury sport pathology sports medicine symptoms and signs therapeutic methods tomography top-level sport |
| synonym |
Hirnkontusion Symptom Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf Diagnose Diagnosemethode Diagnostik Untersuchungsdiagnostik Behandlung Behandlungsmethode Heilverfahren Therapie Physiologie Boxerenzephalopathie CTE Dementia pugilistica Chronisch-traumatische Enzephalopathie Hirngeschädigter Hirnschaden Meningoenzephalitis Pathologie Eiweiss Plasmaprotein Empirie Empirismus Untersuchung, experimentelle Untersuchung Footballspieler Touchdown Fullback Halfback Quarterback Hochleistungssportler Spitzensport Wettbewerbssport Wettkampfsport Hochleistungssportlerin Hochleistungstraining Höchstleistungstraining Spitzensportler Berufssport Berufssportler Professional Professionalismus Profitum |
| synonym_en |
brain concussion cerebral commotion commotio cerebri boxer encephalopathy dementia pugilistica cerebropathy brain disease cranial injury injury of the skull injury of the cranium empirical study high-performance sport |
| journal_facet |
The New England journal of medicine |
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The New England journal of medicine |
| container_issue |
vorab online |
| container_start_page |
vorab online |
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1 |
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BISp |
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JO00000001063 |
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2019 |
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vorab online |
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1791509725841457152 |
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13,546017 |