Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
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| Deutscher übersetzter Titel: | Die Kombination von H-FABP und GFAP erhöht die Fähigkeit, zwischen CT-positiven und CT-negativen Patienten mit leichter traumatischer Hirnverletzung zu differenzieren |
|---|---|
| Autor: | Lagerstedt, Linnéa; Egea-Guerrero, Juan José; Bustamante, Alejandro; Rodríguez-Rodríguez, Ana; El Rahal, Amir; Quintana-Diaz, Manuel; García-Armengol, Roser; Prica, Carmen Melinda; Andereggen, Elisabeth; Rinaldi, Lara; Sarrafzadeh, Asita; Schaller, Karl; Montaner, Joan; Sanchez, Jean-Charles |
| Erschienen in: | PLoS one / Public Library of Science |
| Veröffentlicht: | 13 (2018), 7, Art.-ID e0200394, [13 S.], Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Elektronische Ressource (online) |
| Sprache: | Englisch |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0200394 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201808005448 |
| Quelle: | BISp |
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PU201808005448 |
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db |
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Literatur |
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2019-05-02T11:05:03Z |
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2018-08-01T08:55:58Z |
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BISp |
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Zeitschriftenartikel |
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JO00000100574 |
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JOI201800070100574 |
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PLoS one / Public Library of Science |
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PLoS one / Public Library of Science, 2018, 7 |
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PU201808005448 |
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Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury |
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bisparticle |
| publishDate |
2018 |
| publishDate_facet |
2018 |
| language |
eng |
| title |
Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury |
| spellingShingle |
Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury Computertomographie Diagnostische Verfahren Gehirn Gehirnerschütterung Gehirnerschütterung Hirnfunktion Hirnverletzung Leistungsbeeinflussung Markersubstanz Neurophysiologie Neuropsychologie Schädelhirnverletzung Sportmedizin Sporttraumatologie Zentralnervensystem |
| title_sort |
combining hfabp and gfap increases the capacity to differentiate between ctpositive and ctnegative patients with mild traumatic brain injury |
| title_short |
Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury |
| title_alt |
Die Kombination von H-FABP und GFAP erhöht die Fähigkeit, zwischen CT-positiven und CT-negativen Patienten mit leichter traumatischer Hirnverletzung zu differenzieren |
| title_alt_lang |
deu |
| media_type |
Elektronische Ressource (online) |
| city |
Lawrence (Kans.) |
| abstract |
Mild traumatic brain injury (mTBI) patients may have trauma-induced brain lesions detectable using CT scans. However, most patients will be CT-negative. There is thus a need for an additional tool to detect patients at risk. Single blood biomarkers, such as S100B and GFAP, have been widely studied in mTBI patients, but to date, none seems to perform well enough. In many different diseases, combining several biomarkers into panels has become increasingly interesting for diagnoses and to enhance classification performance. The present study evaluated 13 proteins individually—H-FABP, MMP-1, MMP-3, MMP-9, VCAM, ICAM, SAA, CRP, GSTP, NKDA, PRDX1, DJ-1 and IL-10—for their capacity to differentiate between patients with and without a brain lesion according to CT results. The best performing proteins were then compared and combined with the S100B and GFAP proteins into a CT-scan triage panel. Patients diagnosed with mTBI, with a Glasgow Coma Scale score of 15 and one additional clinical symptom were enrolled at three different European sites. A blood sample was collected at hospital admission, and a CT scan was performed. Patients were divided into two two-centre cohorts and further dichotomised into CT-positive and CT-negative groups for statistical analysis. Single markers and panels were evaluated using Cohort 1. Four proteins—H-FABP, IL-10, S100B and GFAP—showed significantly higher levels in CT-positive patients. The best-performing biomarker was H-FABP, with a specificity of 32% (95% CI 23–40) and sensitivity reaching 100%. The best-performing two-marker panel for Cohort 1, subsequently validated in Cohort 2, was a combination of H-FABP and GFAP, enhancing specificity to 46% (95% CI 36–55). When adding IL-10 to this panel, specificity reached 52% (95% CI 43–61) with 100% sensitivity. These results showed that proteins combined into panels could be used to efficiently classify CT-positive and CT-negative mTBI patients. |
| abstract_lang |
eng |
| abstract_type |
author |
| author2 |
Lagerstedt, Linnéa Egea-Guerrero, Juan José Bustamante, Alejandro Rodríguez-Rodríguez, Ana El Rahal, Amir Quintana-Diaz, Manuel García-Armengol, Roser Prica, Carmen Melinda Andereggen, Elisabeth Rinaldi, Lara Sarrafzadeh, Asita Schaller, Karl Montaner, Joan Sanchez, Jean-Charles |
| author_facet |
Lagerstedt, Linnéa Egea-Guerrero, Juan José Bustamante, Alejandro Rodríguez-Rodríguez, Ana El Rahal, Amir Quintana-Diaz, Manuel García-Armengol, Roser Prica, Carmen Melinda Andereggen, Elisabeth Rinaldi, Lara Sarrafzadeh, Asita Schaller, Karl Montaner, Joan Sanchez, Jean-Charles |
| author2-role |
Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor Autor |
| author2-authorityid |
|
| author_author_facet |
Lagerstedt, Linnéa Egea-Guerrero, Juan José Bustamante, Alejandro Rodríguez-Rodríguez, Ana El Rahal, Amir Quintana-Diaz, Manuel García-Armengol, Roser Prica, Carmen Melinda Andereggen, Elisabeth Rinaldi, Lara Sarrafzadeh, Asita Schaller, Karl Montaner, Joan Sanchez, Jean-Charles |
| author2-synonym |
|
| author2_hierarchy_facet |
0/Autor/ 1/Autor/Lagerstedt, Linnéa/ 0/Autor/ 1/Autor/Egea-Guerrero, Juan José/ 0/Autor/ 1/Autor/Bustamante, Alejandro/ 0/Autor/ 1/Autor/Rodríguez-Rodríguez, Ana/ 0/Autor/ 1/Autor/El Rahal, Amir/ 0/Autor/ 1/Autor/Quintana-Diaz, Manuel/ 0/Autor/ 1/Autor/García-Armengol, Roser/ 0/Autor/ 1/Autor/Prica, Carmen Melinda/ 0/Autor/ 1/Autor/Andereggen, Elisabeth/ 0/Autor/ 1/Autor/Rinaldi, Lara/ 0/Autor/ 1/Autor/Sarrafzadeh, Asita/ 0/Autor/ 1/Autor/Schaller, Karl/ 0/Autor/ 1/Autor/Montaner, Joan/ 0/Autor/ 1/Autor/Sanchez, Jean-Charles/ |
| doi |
10.1371/journal.pone.0200394 |
| spelling |
10.1371/journal.pone.0200394 1932-6203 Computertomographie Diagnostische Verfahren Gehirn Gehirnerschütterung Gehirnerschütterung Hirnfunktion Hirnverletzung Leistungsbeeinflussung Markersubstanz Neurophysiologie Neuropsychologie Schädelhirnverletzung Sportmedizin Sporttraumatologie Zentralnervensystem brain brain function brain injury central nervous system computer tomography concussion of the brain coomotio cerebri craniocerebral injury diagnostic procedures influence on performance marker substance neurophysiology neuropsychology sports medicine sport traumatology Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf Traumatologie Hirnszintigraphie Hirnkontusion Diagnose Diagnosemethode Diagnostik Untersuchungsdiagnostik Gehirnfunktion Hirngeschädigter Hirnschaden Physiologie Zentrales Nervensystem Nervensystem, zentrales traumatology of sport brain concussion cerebral commotion commotio cerebri injury of the brain computerized tomography computed tomography Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury PU201808005448 201808005448 |
| url |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200394 https://dx.doi.org/10.1371/journal.pone.0200394 |
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fulltext fulltext |
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1 1 |
| free_access |
1 |
| issn |
1932-6203 |
| location_hierarchy_facet |
0/USA/ 1/USA/Kansas/ |
| topic |
Computertomographie Diagnostische Verfahren Gehirn Gehirnerschütterung Gehirnerschütterung Hirnfunktion Hirnverletzung Leistungsbeeinflussung Markersubstanz Neurophysiologie Neuropsychologie Schädelhirnverletzung Sportmedizin Sporttraumatologie Zentralnervensystem |
| topic_facet |
Computertomographie Diagnostische Verfahren Gehirn Gehirnerschütterung Gehirnerschütterung Hirnfunktion Hirnverletzung Leistungsbeeinflussung Markersubstanz Neurophysiologie Neuropsychologie Schädelhirnverletzung Sportmedizin Sporttraumatologie Zentralnervensystem |
| topic_en |
brain brain function brain injury central nervous system computer tomography concussion of the brain coomotio cerebri craniocerebral injury diagnostic procedures influence on performance marker substance neurophysiology neuropsychology sports medicine sport traumatology |
| topic_en_facet |
brain brain function brain injury central nervous system computer tomography concussion of the brain coomotio cerebri craniocerebral injury diagnostic procedures influence on performance marker substance neurophysiology neuropsychology sports medicine sport traumatology |
| synonym |
Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf Traumatologie Hirnszintigraphie Hirnkontusion Diagnose Diagnosemethode Diagnostik Untersuchungsdiagnostik Gehirnfunktion Hirngeschädigter Hirnschaden Physiologie Zentrales Nervensystem Nervensystem, zentrales |
| synonym_en |
traumatology of sport brain concussion cerebral commotion commotio cerebri injury of the brain computerized tomography computed tomography |
| journal_facet |
PLoS one / Public Library of Science |
| container_title |
PLoS one / Public Library of Science |
| container_volume |
13 |
| container_issue |
7 |
| container_start_page |
Art.-ID e0200394, [13 S.] |
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1 |
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BISp |
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JO00000100574 |
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2018 |
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7 |
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1791510102075768832 |
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13,54422 |