Physical activity domains and cognitive function over three years in older adults with subjective memory complaints : secondary analysis from the MAPT trial
Deutscher übersetzter Titel: | Körperliche Aktivitätsbereiche und kognitive Funktionen über drei Jahre hinweg bei älteren Erwachsenen mit subjektiven Gedächtnisbeschwerden : sekundäre Analyse aus der MAPT-Studie |
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Autor: | Barreto, Philipe de Souto; Andrieu, Sandrine; Rolland, Yves; Vellas, Bruno |
Erschienen in: | Journal of science and medicine in sport |
Veröffentlicht: | 21 (2018), 1, S. 52-57, Lit. |
Format: | Literatur (SPOLIT) |
Publikationstyp: | Zeitschriftenartikel |
Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
Sprache: | Englisch |
ISSN: | 1440-2440, 1878-1861 |
DOI: | 10.1016/j.jsams.2017.07.019 |
Schlagworte: | |
Online Zugang: | |
Erfassungsnummer: | PU201803002261 |
Quelle: | BISp |
Abstract des Autors
Objectives: We aimed to examine the associations of physical activity (PA) domains (i.e., PA in leisure-time (LTPA), for housework (HPA), or for gardening (GPA)) with cognitive function in older adults with subjective memory complaints (no-dementia) and to investigate if those associations were dependent on the status of apolipoprotein E allele 4 (APOE4), omega-3 levels and mild cognitive impairment (MCI).
Design: Observational prospective secondary analysis using longitudinal data from a randomized controlled trial.
Methods: Participants were 420 French community-dwelling people (aged 75.6 ± 4.4; 66.4% women) randomized into the placebo group. They were assessed at baseline, 6-, 12-, 24- and 36-month using a battery of neuropsychological tests; a composite cognitive Z score was elaborated for all time points. Data on PA come from baseline and was obtained using a self-reported questionnaire.
Results: In time-adjusted analysis, LTPA significantly predicted cognitive function over three years for almost all tests and the composite Z score, with higher LTPA associated with better function; multivariate analysis showed a significant association only for verbal fluency. HPA was not associated to cognitive function, whereas GPA had mixed results. The magnitude of the PA-cognition associations was very weak, being the strongest for LTPA. Stratified analyses showed that the associations between PA and cognitive function were stronger for MCI, people with normal omega-3 index levels, and APOE4 non-carriers.
Conclusions: PA domain is an important aspect to take into account when examining the associations between PA and cognitive function. Biomarkers of cognitive function may modulate the PA-cognition associations.