Acute plasma tau relates to prolonged return to play after concussion
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| Deutscher übersetzter Titel: | Akutes Tau-Plasma nach einer Gehirnerschütterung bedingt eine längere Pause bis zum nächsten Sporteinsatz |
|---|---|
| Autor: | Gill, Jessica; Merchant-Borna, Kian; Jeromin, Andreas; Livingston, Whitney; Bazarian, Jeffrey |
| Erschienen in: | Neurology |
| Veröffentlicht: | 88 (2017), 6, S. 595-602, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Zeitschriftenartikel |
| Medienart: | Elektronische Ressource (online) Gedruckte Ressource |
| Sprache: | Englisch |
| ISSN: | 0028-3878, 1526-632X |
| DOI: | 10.1212/WNL.0000000000003587 |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201701000646 |
| Quelle: | BISp |
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PU201701000646 |
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db |
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Literatur |
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2019-05-03T08:43:03Z |
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2017-01-23T13:33:50Z |
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BISp |
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Zeitschriftenartikel |
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JO00000001059 |
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JOI201700060001059 |
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Neurology |
| hierarchy_parent_title |
Neurology, 2017, 6 |
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PU201701000646 |
| is_hierarchy_title |
Acute plasma tau relates to prolonged return to play after concussion |
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0595 |
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bisparticle |
| publishDate |
2017 |
| publishDate_facet |
2017 |
| language |
eng |
| title |
Acute plasma tau relates to prolonged return to play after concussion |
| spellingShingle |
Acute plasma tau relates to prolonged return to play after concussion Analyse Betreuung, sportmedizinische Einsatzbereitschaft Enzephalopathie Enzephalopathie, chronisch-traumatische Gehirn Gehirnerschütterung Gehirnerschütterung Markersubstanz Neurologie Plasmaprotein Rehabilitation, posttraumatische Schädelhirnverletzung Schädelverletzung Spielfähigkeit Sportmedizin Sporttraumatologie Sportverletzung Sportwissenschaft Untersuchung, vergleichende |
| title_sort |
acute plasma tau relates to prolonged return to play after concussion |
| title_short |
Acute plasma tau relates to prolonged return to play after concussion |
| title_alt |
Akutes Tau-Plasma nach einer Gehirnerschütterung bedingt eine längere Pause bis zum nächsten Sporteinsatz |
| title_alt_lang |
deu |
| media_type |
Elektronische Ressource (online) Gedruckte Ressource |
| city |
Hagerstown (Mary.) |
| abstract |
Objective: To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP).
Methods: Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at baseline. SRC athletes were grouped by long (>10 days, n = 23) and short (≤10 days, n = 18) RTP. Total tau was measured using an ultrasensitive immunoassay.
Results: Both SRC and athlete controls had significantly higher mean tau at baseline compared to nonathlete healthy controls (F101,3 = 19.644, p < 0.01). Compared to SRC athletes with short RTP, those with long RTP had higher tau concentrations overall, after controlling for sex (F39,1 = 3.59, p = 0.022), compared to long RTP athletes, at 6 (p < 0.01), 24 (p < 0.01), and 72 hours (p = 0.02). Receiver operator characteristic analyses showed that higher plasma tau 6 hours post-SRC was a significant predictor of RTP >10 days (area under the curve 0.81; 95% confidence interval 0.62–0.97, p = 0.01).
Conclusions: Elevated plasma tau concentration within 6 hours following a SRC was related to having a prolonged RTP, suggesting that tau levels may help inform RTP. |
| abstract_lang |
eng |
| abstract_type |
author |
| author2 |
Gill, Jessica Merchant-Borna, Kian Jeromin, Andreas Livingston, Whitney Bazarian, Jeffrey |
| author_facet |
Gill, Jessica Merchant-Borna, Kian Jeromin, Andreas Livingston, Whitney Bazarian, Jeffrey |
| author2-role |
Autor Autor Autor Autor Autor |
| author2-authorityid |
|
| author_author_facet |
Gill, Jessica Merchant-Borna, Kian Jeromin, Andreas Livingston, Whitney Bazarian, Jeffrey |
| author2-synonym |
|
| author2_hierarchy_facet |
0/Autor/ 1/Autor/Gill, Jessica/ 0/Autor/ 1/Autor/Merchant-Borna, Kian/ 0/Autor/ 1/Autor/Jeromin, Andreas/ 0/Autor/ 1/Autor/Livingston, Whitney/ 0/Autor/ 1/Autor/Bazarian, Jeffrey/ |
| doi |
10.1212/WNL.0000000000003587 |
| spelling |
10.1212/WNL.0000000000003587 0028-3878 1526-632X NEURA 207147-2 Analyse Betreuung, sportmedizinische Einsatzbereitschaft Enzephalopathie Enzephalopathie, chronisch-traumatische Gehirn Gehirnerschütterung Gehirnerschütterung Markersubstanz Neurologie Plasmaprotein Rehabilitation, posttraumatische Schädelhirnverletzung Schädelverletzung Spielfähigkeit Sportmedizin Sporttraumatologie Sportverletzung Sportwissenschaft Untersuchung, vergleichende action, readiness for analysis brain chronic traumatic encephalopathy comparative study concussion of the brain coomotio cerebri craniocerebral injury encephalopathy marker substance neurology plasma protein playing ability post-traumatic rehabilitation skull injury sport injury sport science sports medical care sports medicine sport traumatology Theorie der Körpererziehung Theorie der Leibesübungen Theorie der Leibeserziehung Analyse, methodische Vergleich Betreuung, sportärztliche Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf Hirnszintigraphie Hirnkontusion Verletzung Verletzung, sportartspezifische Traumatologie Spielvermögen Boxerenzephalopathie CTE Dementia pugilistica Chronisch-traumatische Enzephalopathie Hirngeschädigter Hirnschaden Meningoenzephalitis exercise science sport and exercise science comparative investigation brain concussion cerebral commotion commotio cerebri traumatology of sport cranial injury injury of the skull injury of the cranium playing proficiency boxer encephalopathy dementia pugilistica cerebropathy brain disease Acute plasma tau relates to prolonged return to play after concussion PU201701000646 201701000646 |
| url |
https://dx.doi.org/10.1212/WNL.0000000000003587 http://www.neurology.org/content/early/2017/01/06/WNL.0000000000003587.short?sid=844bf240-4074-49ce-b62f-d1b1588155c3 |
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fulltext fulltext |
| url-free |
1 1 |
| free_access |
1 |
| issn |
0028-3878 1526-632X |
| coden |
NEURA |
| zdb |
207147-2 |
| location_hierarchy_facet |
0/USA/ 1/USA/Maryland/ |
| topic |
Analyse Betreuung, sportmedizinische Einsatzbereitschaft Enzephalopathie Enzephalopathie, chronisch-traumatische Gehirn Gehirnerschütterung Gehirnerschütterung Markersubstanz Neurologie Plasmaprotein Rehabilitation, posttraumatische Schädelhirnverletzung Schädelverletzung Spielfähigkeit Sportmedizin Sporttraumatologie Sportverletzung Sportwissenschaft Untersuchung, vergleichende |
| topic_facet |
Analyse Betreuung, sportmedizinische Einsatzbereitschaft Enzephalopathie Enzephalopathie, chronisch-traumatische Gehirn Gehirnerschütterung Gehirnerschütterung Markersubstanz Neurologie Plasmaprotein Rehabilitation, posttraumatische Schädelhirnverletzung Schädelverletzung Spielfähigkeit Sportmedizin Sporttraumatologie Sportverletzung Sportwissenschaft Untersuchung, vergleichende |
| topic_en |
action, readiness for analysis brain chronic traumatic encephalopathy comparative study concussion of the brain coomotio cerebri craniocerebral injury encephalopathy marker substance neurology plasma protein playing ability post-traumatic rehabilitation skull injury sport injury sport science sports medical care sports medicine sport traumatology |
| topic_en_facet |
action, readiness for analysis brain chronic traumatic encephalopathy comparative study concussion of the brain coomotio cerebri craniocerebral injury encephalopathy marker substance neurology plasma protein playing ability post-traumatic rehabilitation skull injury sport injury sport science sports medical care sports medicine sport traumatology |
| synonym |
Theorie der Körpererziehung Theorie der Leibesübungen Theorie der Leibeserziehung Analyse, methodische Vergleich Betreuung, sportärztliche Medizin Geschichte der Medizin Untersuchung, sportmedizinische Wasserdampf Hirnszintigraphie Hirnkontusion Verletzung Verletzung, sportartspezifische Traumatologie Spielvermögen Boxerenzephalopathie CTE Dementia pugilistica Chronisch-traumatische Enzephalopathie Hirngeschädigter Hirnschaden Meningoenzephalitis |
| synonym_en |
exercise science sport and exercise science comparative investigation brain concussion cerebral commotion commotio cerebri traumatology of sport cranial injury injury of the skull injury of the cranium playing proficiency boxer encephalopathy dementia pugilistica cerebropathy brain disease |
| journal_facet |
Neurology |
| container_title |
Neurology |
| container_volume |
88 |
| container_issue |
6 |
| container_start_page |
S. 595-602 |
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1 |
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BISp |
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JO00000001059 |
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2017 |
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6 |
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1791510934241411072 |
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13,545771 |