Acute plasma tau relates to prolonged return to play after concussion

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Deutscher übersetzter Titel:Akutes Tau-Plasma nach einer Gehirnerschütterung bedingt eine längere Pause bis zum nächsten Sporteinsatz
Autor:Gill, Jessica; Merchant-Borna, Kian; Jeromin, Andreas; Livingston, Whitney; Bazarian, Jeffrey
Erschienen in:Neurology
Veröffentlicht:88 (2017), 6, S. 595-602, Lit.
Format: Literatur (SPOLIT)
Publikationstyp: Zeitschriftenartikel
Medienart: Elektronische Ressource (online) Gedruckte Ressource
Sprache:Englisch
ISSN:0028-3878, 1526-632X
DOI:10.1212/WNL.0000000000003587
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Erfassungsnummer:PU201701000646
Quelle:BISp
TY  - JOUR
AU  - Gill, Jessica
A2  - Gill, Jessica
A2  - Merchant-Borna, Kian
A2  - Jeromin, Andreas
A2  - Livingston, Whitney
A2  - Bazarian, Jeffrey
DB  - BISp
DP  - BISp
KW  - Analyse
KW  - Betreuung, sportmedizinische
KW  - Einsatzbereitschaft
KW  - Enzephalopathie
KW  - Enzephalopathie, chronisch-traumatische
KW  - Gehirn
KW  - Gehirnerschütterung
KW  - Markersubstanz
KW  - Neurologie
KW  - Plasmaprotein
KW  - Rehabilitation, posttraumatische
KW  - Schädelhirnverletzung
KW  - Schädelverletzung
KW  - Spielfähigkeit
KW  - Sportmedizin
KW  - Sporttraumatologie
KW  - Sportverletzung
KW  - Sportwissenschaft
KW  - Untersuchung, vergleichende
LA  - eng
TI  - Acute plasma tau relates to prolonged return to play after concussion
TT  - Akutes Tau-Plasma nach einer Gehirnerschütterung bedingt eine längere Pause bis zum nächsten Sporteinsatz
PY  - 2017
N2  - Objective: To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP).  Methods: Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at baseline. SRC athletes were grouped by long (>10 days, n = 23) and short (≤10 days, n = 18) RTP. Total tau was measured using an ultrasensitive immunoassay.  Results: Both SRC and athlete controls had significantly higher mean tau at baseline compared to nonathlete healthy controls (F101,3 = 19.644, p < 0.01). Compared to SRC athletes with short RTP, those with long RTP had higher tau concentrations overall, after controlling for sex (F39,1 = 3.59, p = 0.022), compared to long RTP athletes, at 6 (p < 0.01), 24 (p < 0.01), and 72 hours (p = 0.02). Receiver operator characteristic analyses showed that higher plasma tau 6 hours post-SRC was a significant predictor of RTP >10 days (area under the curve 0.81; 95% confidence interval 0.62–0.97, p = 0.01).  Conclusions: Elevated plasma tau concentration within 6 hours following a SRC was related to having a prolonged RTP, suggesting that tau levels may help inform RTP.
L2  - https://dx.doi.org/10.1212/WNL.0000000000003587
L2  - http://www.neurology.org/content/early/2017/01/06/WNL.0000000000003587.short?sid=844bf240-4074-49ce-b62f-d1b1588155c3
DO  - 10.1212/WNL.0000000000003587
SP  - S. 595-602
SN  - 0028-3878
JO  - Neurology
IS  - 6
VL  - 88
M3  - Elektronische Ressource (online)
M3  - Gedruckte Ressource
ID  - PU201701000646
ER  -