Acute plasma tau relates to prolonged return to play after concussion

Titel: Acute plasma tau relates to prolonged return to play after concussion
Deutscher übersetzter Titel: Akutes Tau-Plasma nach einer Gehirnerschütterung bedingt eine längere Pause bis zum nächsten Sporteinsatz
Autor: Gill, Jessica; Merchant-Borna, Kian; Jeromin, Andreas; Livingston, Whitney; Bazarian, Jeffrey
Zeitschriftentitel: Neurology
Format: Zeitschriften­artikel
Medienart: Elektronische Ressource (online); Gedruckte Ressource
Sprache: Englisch
Veröffentlicht: 88 (2017), 6, S. 595-602, Lit.
Schlagworte: Analyse; Betreuung, sportmedizinische; Boxerenzephalopathie; Boxerenzephalopathie; Boxerenzephalopathie; Einsatzbereitschaft; Enzephalopathie; Gehirn; Gehirnerschütterung; Markersubstanz; Neurologie; Plasmaprotein; Rehabilitation, posttraumatische; Schädelhirnverletzung; Schädelverletzung; Spielfähigkeit; Sportmedizin; Sporttraumatologie; Sportverletzung; Sportwissenschaft; Untersuchung, vergleichende;
Erfassungsnummer: PU201701000646
Quelle: BISp
Gespeichert in:

Abstract des Autors

Objective: To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP).

Methods: Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at baseline. SRC athletes were grouped by long (>10 days, n = 23) and short (≤10 days, n = 18) RTP. Total tau was measured using an ultrasensitive immunoassay.

Results: Both SRC and athlete controls had significantly higher mean tau at baseline compared to nonathlete healthy controls (F101,3 = 19.644, p < 0.01). Compared to SRC athletes with short RTP, those with long RTP had higher tau concentrations overall, after controlling for sex (F39,1 = 3.59, p = 0.022), compared to long RTP athletes, at 6 (p < 0.01), 24 (p < 0.01), and 72 hours (p = 0.02). Receiver operator characteristic analyses showed that higher plasma tau 6 hours post-SRC was a significant predictor of RTP >10 days (area under the curve 0.81; 95% confidence interval 0.62–0.97, p = 0.01).

Conclusions: Elevated plasma tau concentration within 6 hours following a SRC was related to having a prolonged RTP, suggesting that tau levels may help inform RTP.

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