TY  - JOUR
AU  - Wright, Alexander D.
A2  - Wright, Alexander D.
A2  - Jarrett, Michael
A2  - Vavasour, Irene
A2  - Shahinfard, Elham
A2  - Kolind, Shannon
A2  - Donkelaar, Paul van
A2  - Taunton, Jack
A2  - Li, David
A2  - Rauscher, Alexander
DB  - BISp
DP  - BISp
KW  - Betreuung, sportmedizinische
KW  - Gehirn
KW  - Gehirnerschütterung
KW  - Hirnstoffwechsel
KW  - Leistungsbeeinflussung
KW  - Neurophysiologie
KW  - Neuropsychologie
KW  - Schädelhirnverletzung
KW  - Sportmedizin
KW  - Wasserhaushalt
KW  - Wirkung
KW  - Zustand, posttraumatischer
LA  - eng
TI  - Myelin water fraction is transiently reduced after a single mild Traumatic Brain Injury – a prospective cohort study in Collegiate hockey players
TT  - Der Myelin-Wasseranteil wird nach einem einzigen leichten Schädelhirntrauma vorübergehend reduziert - eine prospektive Kohortenstudie unter Hockey-Spieler auf dem College
PY  - 2016
N2  - Impact-related mild traumatic brain injuries (mTBI) are a major public health concern, and remain as one of the most poorly understood injuries in the field of neuroscience. Currently, the diagnosis and management of such injuries are based largely on patient-reported symptoms. An improved understanding of the underlying pathophysiology of mTBI is urgently needed in order to develop better diagnostic and management protocols. Specifically, dynamic post-injury changes to the myelin sheath in the human brain have not been examined, despite ‘compromised white matter integrity’ often being described as a consequence of mTBI. In this preliminary cohort study, myelin water imaging was used to prospectively evaluate changes in myelin water fraction, derived from the T2 decay signal, in two varsity hockey teams (45 players) over one season of athletic competition. 11 players sustained a concussion during competition, and were scanned at 72 hours, 2 weeks, and 2 months post-injury. Results demonstrated a reduction in myelin water fraction at 2 weeks post-injury in several brain areas relative to preseason scans, including the splenium of the corpus callosum, right posterior thalamic radiation, left superior corona radiata, left superior longitudinal fasciculus, and left posterior limb of the internal capsule. Myelin water fraction recovered to pre-season values by 2 months post-injury. These results may indicate transient myelin disruption following a single mTBI, with subsequent remyelination of affected neurons. Myelin disruption was not apparent in the athletes who did not experience a concussion, despite exposure to repetitive subconcussive trauma over a season of collegiate hockey. These findings may help to explain many of the metabolic and neurological deficits observed clinically following mTBI.
L2  - https://dx.doi.org/10.1371/journal.pone.0150215
L2  - http://journals.plos.org/plosone/article/asset?id=10.1371%2Fjournal.pone.0150215.PDF
DO  - 10.1371/journal.pone.0150215
SP  - Art.-ID e0150215; [16 S.]
SN  - 1932-6203
JO  - PLoS one / Public Library of Science
IS  - 2
VL  - 11
M3  - Elektronische Ressource (online)
ID  - PU201603001280
ER  -