TY  - JOUR
AU  - Ahtiainen, Juha P.
A2  - Ahtiainen, Juha P.
A2  - Lehti, Maarit
A2  - Hulmi, Juha J.
A2  - Kraemer, William J.
A2  - Alen, Markku
A2  - Nyman, Kai
A2  - Selänne, Harri
A2  - Pakarinen, Arto
A2  - Kovanen, Vuokko
A2  - Mero, Antti A.
A2  - Häkkinen, Keijo
A2  - Komulainen, Jyrki
DB  - BISp
DP  - BISp
KW  - Androgen
KW  - Insulin
KW  - Krafttraining
KW  - Mann
KW  - Rezeptor
KW  - Skelettmuskulatur
KW  - Trainierter
KW  - Trainingswissenschaft
KW  - Wachstumsfaktor
LA  - eng
TI  - Recovery after heavy resistance exercise and skeletal muscle androgen receptor and insulin-like growth factor-I isoform expression in strength trained men
TT  - Erholung nach intensivem Krafttraining und der skelettale Muskel-Androgen-Rezeptor- und insulinartige Wachstumsfaktor-I-Isoform-Ausdruck bei krafftrainierten Männern
PY  - 2011
N2  - The effects of heavy resistance exercise on skeletal muscle androgen receptor (AR) protein concentration and mRNAs of AR, insulin-like growth factor-I (IGF)-IEa, and mechano growth factor (MGF) expression were examined from biopsies of vastus lateralis (VL) muscle before and 48 hours after heavy resistance exercise (5 × 10 repetition maximum [RM] leg press and 4 × 10RM squats) in 8 adult strength trained men. The present exercise induced an acute decrease in maximal isometric force and increased serum total testosterone (T) and free testosterone (FT) concentrations. During 2 recovery days, maximal isometric force and subjective perception of physical fitness remained significantly lowered, whereas serum creatine kinase activity, subjective muscle soreness, and muscle swelling (i.e., thickness of VL by ultrasound) were significantly increased compared to pre-exercise values. Subjective perception of physical fitness was followed up to 7 days, and by 6 days postexercise, it was elevated above the pre-exercise level. Basal T and FT concentrations remained unaltered after the exercise. No statistically significant changes were observed in AR protein or mRNA expression, but IGF-IEa (p < 0.05) and MGF (p < 0.05) mRNA expression were increased compared to pre-exercise levels. These findings indicate that IGF-IEa and MGF responses may be related to acute regenerative processes in muscle because of exercise and may contribute to muscular adaptation to resistance exercise. Subjective perception of physical fitness suggests that recovery over a pre-exercise level of the present type of heavy resistance exercise can take approximately 6 days. Verf.-ReferatThe effects of heavy resistance exercise on skeletal muscle androgen receptor (AR) protein concentration and mRNAs of AR, insulin-like growth factor-I (IGF)-IEa, and mechano growth factor (MGF) expression were examined from biopsies of vastus lateralis (VL) muscle before and 48 hours after heavy resistance exercise (5 × 10 repetition maximum [RM] leg press and 4 × 10RM squats) in 8 adult strength trained men. The present exercise induced an acute decrease in maximal isometric force and increased serum total testosterone (T) and free testosterone (FT) concentrations. During 2 recovery days, maximal isometric force and subjective perception of physical fitness remained significantly lowered, whereas serum creatine kinase activity, subjective muscle soreness, and muscle swelling (i.e., thickness of VL by ultrasound) were significantly increased compared to pre-exercise values. Subjective perception of physical fitness was followed up to 7 days, and by 6 days postexercise, it was elevated above the pre-exercise level. Basal T and FT concentrations remained unaltered after the exercise. No statistically significant changes were observed in AR protein or mRNA expression, but IGF-IEa (p < 0.05) and MGF (p < 0.05) mRNA expression were increased compared to pre-exercise levels. These findings indicate that IGF-IEa and MGF responses may be related to acute regenerative processes in muscle because of exercise and may contribute to muscular adaptation to resistance exercise. Subjective perception of physical fitness suggests that recovery over a pre-exercise level of the present type of heavy resistance exercise can take approximately 6 days. Verf.-Referat
L2  - https://dx.doi.org/10.1519/JSC.0b013e318202e449
DO  - 10.1519/JSC.0b013e318202e449
SP  - S. 767-777
SN  - 1064-8011
JO  - Journal of strength and conditioning research
IS  - 3
VL  - 25
M3  - Gedruckte Ressource
M3  - Elektronische Ressource (online)
ID  - PU201105004742
ER  -