Alternative steroid profiling : reference ranges for urinary endogenous steroids in a Caucasian population of athletes
| Deutscher übersetzter Titel: | Alternative Steroidprofilierung : Referenzbereiche für endogene Steroide im Urin bei einer Stichprobe von kaukasischen Athleten |
|---|---|
| Autor: | Renterghem, P. van; Eenoo, P. van; Geyer, Hans; Schänzer, Wilhelm; Delbeke, F.T. |
| Erschienen in: | Recent advances in doping analysis (17) : Proceedings of the Manfred Donike Workshop ; 27th Cologne Workshop on Dope Analysis ; 1st to 6th March 2009 |
| Veröffentlicht: | Köln: Sportverl. Strauß (Verlag), 2009, S. 81-90, Lit. |
| Format: | Literatur (SPOLIT) |
| Publikationstyp: | Sammelwerksbeitrag |
| Medienart: | Gedruckte Ressource |
| Sprache: | Englisch |
| Schlagworte: | |
| Online Zugang: | |
| Erfassungsnummer: | PU201101000573 |
| Quelle: | BISp |
Abstract
A comprehensive screening method for steroid profiling was developed covering 29 steroid metabolites. Additionally, 10 steroid ratios were evaluated. Based upon a reference population of more than 3000 samples from healthy athletes the reference values were established at 3 different levels: 97.5%, 99% and 99.9%. Using the extended method and the reference ranges, 2 additional metabolites from 6-oxo-Adion were identified; 6ß-OH-Andro and 6ß-OH-Etio could stretch the detection time for 6-oxo-Adion administration until 36h. In the case of 7-keto-DHEA, 7α-OH-T can be regarded as additional specific metabolite. 7-keto-DHEA can be detected 36h after intake although steroid ratios indicate prolonged changes up to 48h of the steroid profile. Aus dem Text